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Gc GC, vitamin D binding protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 24384, updated on 9-Dec-2024

Summary

Official Symbol
Gcprovided by RGD
Official Full Name
GC, vitamin D binding proteinprovided by RGD
Primary source
RGD:2667
See related
EnsemblRapid:ENSRNOG00000003119 AllianceGenome:RGD:2667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
DBP; VDB; Vdbp; DBP02
Summary
Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 38784.0) See more
Orthologs
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Genomic context

Location:
14p22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (18916255..18951670)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (18632146..18667563)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (20267023..20302577)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1, motif 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene neuropeptide FF receptor 2 Neighboring gene signal recognition particle 19, pseudogene 1 Neighboring gene solute carrier family 4 member 4 Neighboring gene gem-associated protein 8-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding  
enables actin binding  
enables actin binding  
enables calcidiol binding  
enables calcidiol binding  
enables protein binding PubMed 
enables vitamin D binding  
enables vitamin D binding PubMed 
enables vitamin D binding  
enables vitamin D binding PubMed 
enables vitamin transmembrane transporter activity  
Process Evidence Code Pubs
involved_in female pregnancy PubMed 
involved_in lactation PubMed 
involved_in response to estradiol PubMed 
involved_in response to nutrient levels PubMed 
involved_in response to steroid hormone PubMed 
involved_in vitamin D metabolic process  
involved_in vitamin D metabolic process  
acts_upstream_of_or_within vitamin D metabolic process  
involved_in vitamin transmembrane transport  
Component Evidence Code Pubs
located_in axon PubMed 
is_active_in cytoplasm  
located_in extracellular space PubMed 
located_in extracellular space  
located_in membrane  
located_in perinuclear region of cytoplasm PubMed 

General protein information

Preferred Names
vitamin D-binding protein
Names
gc-globulin
group specific component
NP_036696.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012564.3NP_036696.2  vitamin D-binding protein precursor

    See identical proteins and their annotated locations for NP_036696.2

    Status: VALIDATED

    Source sequence(s)
    BC078891
    UniProtKB/Swiss-Prot
    P04276
    UniProtKB/TrEMBL
    A6KKH1, F7FJ08, Q68FY4
    Related
    ENSRNOP00000004174.2, ENSRNOT00000004174.6
    Conserved Domains (2) summary
    smart00103
    Location:19201
    ALBUMIN; serum albumin
    pfam09164
    Location:405469
    VitD-bind_III; Vitamin D binding protein, domain III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    18916255..18951670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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