U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Nr1d1 nuclear receptor subfamily 1, group D, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 217166, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr1d1provided by MGI
    Official Full Name
    nuclear receptor subfamily 1, group D, member 1provided by MGI
    Primary source
    MGI:MGI:2444210
    See related
    Ensembl:ENSMUSG00000020889 AllianceGenome:MGI:2444210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A530070C09Rik
    Summary
    This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (Arntl). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]
    Expression
    Broad expression in adrenal adult (RPKM 224.5), lung adult (RPKM 118.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nr1d1 in Genome Data Viewer
    Location:
    11 D; 11 62.66 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98658758..98666233, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98767932..98775377, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 24 Neighboring gene predicted gene, 22059 Neighboring gene predicted gene, 31252 Neighboring gene STARR-positive B cell enhancer ABC_E3017 Neighboring gene thyroid hormone receptor alpha Neighboring gene STARR-positive B cell enhancer ABC_E3018 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:98636882-98637065 Neighboring gene predicted gene, 31862 Neighboring gene STARR-positive B cell enhancer ABC_E468 Neighboring gene male specific lethal 1 Neighboring gene predicted gene 12359

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA-binding transcription factor activity PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific  
    enables E-box binding PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding PubMed 
    enables heme binding  
    enables heme binding  
    enables nuclear receptor activity  
    enables protein binding PubMed 
    enables sequence-specific double-stranded DNA binding  
    enables transcription cis-regulatory region binding  
    enables transcription corepressor binding  
    enables transcription corepressor binding  
    enables zinc ion binding  
    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in cell differentiation  
    involved_in cell differentiation  
    involved_in cellular response to interleukin-1 PubMed 
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to tumor necrosis factor PubMed 
    involved_in cholesterol homeostasis PubMed 
    involved_in circadian regulation of gene expression PubMed 
    acts_upstream_of_or_within circadian rhythm PubMed 
    involved_in circadian rhythm PubMed 
    involved_in circadian temperature homeostasis PubMed 
    involved_in glycogen biosynthetic process PubMed 
    involved_in hormone-mediated signaling pathway  
    involved_in intracellular glucose homeostasis  
    involved_in intracellular glucose homeostasis  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of astrocyte activation PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction PubMed 
    involved_in negative regulation of cold-induced thermogenesis PubMed 
    involved_in negative regulation of inflammatory response PubMed 
    involved_in negative regulation of microglial cell activation PubMed 
    involved_in negative regulation of neuroinflammatory response PubMed 
    involved_in negative regulation of toll-like receptor 4 signaling pathway  
    involved_in negative regulation of toll-like receptor 4 signaling pathway  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of transcription by RNA polymerase II  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of bile acid biosynthetic process PubMed 
    involved_in positive regulation of circadian rhythm  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in proteasomal protein catabolic process PubMed 
    involved_in protein destabilization PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription PubMed 
    involved_in regulation of circadian rhythm PubMed 
    involved_in regulation of circadian rhythm  
    involved_in regulation of circadian sleep/wake cycle PubMed 
    involved_in regulation of fat cell differentiation PubMed 
    involved_in regulation of hepatic stellate cell activation  
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of lipid metabolic process PubMed 
    involved_in regulation of type B pancreatic cell proliferation PubMed 
    involved_in response to leptin  
    involved_in response to leptin PubMed 
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in dendrite PubMed 
    located_in dendrite  
    located_in dendritic spine PubMed 
    located_in neuronal cell body  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    nuclear receptor subfamily 1 group D member 1
    Names
    EAR-1
    REV-ERBalpha
    Rev-ErbA-alpha protein
    V-erbA-related protein 1
    nuclear receptor protein
    orphan nuclear receptor
    rev-erb alpha
    rev-erbA alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145434.4NP_663409.2  nuclear receptor subfamily 1 group D member 1

      See identical proteins and their annotated locations for NP_663409.2

      Status: VALIDATED

      Source sequence(s)
      AK155597, CD776678
      Consensus CDS
      CCDS25363.1
      UniProtKB/Swiss-Prot
      Q3UJJ1, Q3UV55, Q62171, Q6EEZ6, Q922A5, Q9ESY4
      Related
      ENSMUSP00000069505.7, ENSMUST00000064941.7
      Conserved Domains (2) summary
      cd07166
      Location:128216
      NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
      cl11397
      Location:419612
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      98658758..98666233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156590.1XP_036012483.1  nuclear receptor subfamily 1 group D member 1 isoform X1

      Conserved Domains (2) summary
      cl02596
      Location:49110
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
      cl11397
      Location:313506
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RNA

    1. XR_004936927.1 RNA Sequence

    Loading
    Loading
    External link. Please review our privacy policy.