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    Acadvl Acyl-CoA dehydrogenase very long chain [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37217, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acadvlprovided by FlyBase
    Official Full Name
    Acyl-CoA dehydrogenase very long chainprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034432
    Locus tag
    Dmel_CG7461
    See related
    AllianceGenome:FB:FBgn0034432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg7461; CG7461; dACADVL; Dmel\CG7461
    Summary
    Predicted to enable fatty-acyl-CoA binding activity; long-chain fatty acyl-CoA dehydrogenase activity; and very-long-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA dehydrogenase. Predicted to be located in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic salivary gland duct; larval muscle system; and salivary gland body primordium. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Acadvl in Genome Data Viewer
    Location:
    56C9-56C10; 2-88 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19305172..19307445)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15192677..15194950)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Myb-interacting protein 40 Neighboring gene TAK1-associated binding protein 2 Neighboring gene Endophilin B Neighboring gene Rad, Gem/Kir family member 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acyl-CoA dehydrogenase activity  
    enables fatty-acyl-CoA binding  
    enables flavin adenine dinucleotide binding  
    enables long-chain fatty acyl-CoA dehydrogenase activity  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity  
    Component Evidence Code Pubs
    located_in mitochondrion  

    General protein information

    Preferred Names
    Acyl-CoA dehydrogenase very long chain
    Names
    Acadvl-PB
    Acadvl-PC
    CG7461-PB
    CG7461-PC
    drosophila very-long chain ACAD
    NP_001286611.1
    NP_611409.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19305172..19307445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299682.1 → NP_001286611.1  Acyl-CoA dehydrogenase very long chain, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286611.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ2, C9QPI7
      Conserved Domains (2) summary
      cd01161
      Location:45 → 454
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:67 → 446
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
    2. NM_137565.3 → NP_611409.2  Acyl-CoA dehydrogenase very long chain, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611409.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBJ2, C9QPI7
      Conserved Domains (2) summary
      cd01161
      Location:45 → 454
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:67 → 446
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
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