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par-4 Serine/threonine-protein kinase par-4 [ Caenorhabditis elegans ]

Gene ID: 180185, updated on 9-Dec-2024

Summary

Official Symbol
par-4
Official Full Name
Serine/threonine-protein kinase par-4
Primary source
WormBase:WBGene00003919
Locus tag
CELE_Y59A8B.14
See related
AllianceGenome:WB:WBGene00003919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity and protein serine/threonine kinase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; determination of adult lifespan; and positive regulation of dauer larval development. Located in cell cortex. Is expressed in several structures, including gonad. Used to study Peutz-Jeghers syndrome. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See par-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (18098687..18106405)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MATH domain-containing protein Neighboring gene Synthetic with Lin-35/Rb Neighboring gene Deoxyribonuclease TATDN2 Neighboring gene ncRNA Neighboring gene pseudo

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding  
enables calmodulin binding PubMed 
enables metal ion binding  
enables protein binding PubMed 
enables protein kinase activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity PubMed 
Component Evidence Code Pubs
located_in cell cortex PubMed 
located_in cell cortex  
located_in cytoplasm PubMed 
located_in cytoplasm  

General protein information

Preferred Names
Serine/threonine-protein kinase par-4
NP_001366977.1
  • Confirmed by transcript evidence
NP_001367284.1
  • Confirmed by transcript evidence
NP_001367285.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    18098687..18106405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380857.2NP_001366977.1  Serine/threonine-protein kinase par-4 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EES7, G5EGA8, Q9GN62, Q9Y0C1
    Conserved Domains (1) summary
    cl21453
    Location:189446
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001380858.1NP_001367285.1  Serine/threonine-protein kinase par-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21453
    Location:185442
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001380859.1NP_001367284.1  Serine/threonine-protein kinase par-4 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21453
    Location:48305
    PKc_like; Protein Kinases, catalytic domain
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