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Chst4 carbohydrate sulfotransferase 4 [ Mus musculus (house mouse) ]

Gene ID: 26887, updated on 9-Dec-2024

Summary

Official Symbol
Chst4provided by MGI
Official Full Name
carbohydrate sulfotransferase 4provided by MGI
Primary source
MGI:MGI:1349479
See related
Ensembl:ENSMUSG00000035930 AllianceGenome:MGI:1349479
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GST-3; Gn6st-2; HEC-GlcNAc6ST
Summary
Enables N-acetylglucosamine 6-O-sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within leukocyte tethering or rolling and protein sulfation. Predicted to be located in Golgi membrane. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; genitourinary system; immune system; liver; and nervous system. Orthologous to human CHST4 (carbohydrate sulfotransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in colon adult (RPKM 33.9), large intestine adult (RPKM 14.4) and 6 other tissues See more
Orthologs
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Genomic context

See Chst4 in Genome Data Viewer
Location:
8 D3; 8 57.38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110755776..110766033, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110029075..110039401, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22664 Neighboring gene tyrosine aminotransferase Neighboring gene RIKEN cDNA 1700064F23 gene Neighboring gene STARR-seq mESC enhancer starr_22666 Neighboring gene RIKEN cDNA 8030455M16 gene Neighboring gene zinc finger protein 612

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi membrane  
is_active_in trans-Golgi network  
located_in trans-Golgi network  

General protein information

Preferred Names
carbohydrate sulfotransferase 4
Names
L-selectin ligand sulfotransferase
LSST
N-acetylglucosamine 6-O-sulfotransferase 2
carbohydrate (chondroitin 6/keratan) sulfotransferase 4
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 3
glcNAc6ST-2
high endothelial cell GlcNAC-6-sulphotransferase
high endothelial cells N-acetylglucosamine 6-O-sulfotransferase
NP_001411745.1
NP_001411746.1
NP_036128.3
XP_006531108.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424816.1NP_001411745.1  carbohydrate sulfotransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC124409
    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
  2. NM_001424817.1NP_001411746.1  carbohydrate sulfotransferase 4

    Status: VALIDATED

    Source sequence(s)
    AC124409
    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
  3. NM_011998.5NP_036128.3  carbohydrate sulfotransferase 4

    See identical proteins and their annotated locations for NP_036128.3

    Status: VALIDATED

    Source sequence(s)
    AC124409
    Consensus CDS
    CCDS22659.1
    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
    Related
    ENSMUSP00000104845.3, ENSMUST00000109222.4
    Conserved Domains (1) summary
    cl21551
    Location:44297
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    110755776..110766033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531045.4XP_006531108.1  carbohydrate sulfotransferase 4 isoform X1

    See identical proteins and their annotated locations for XP_006531108.1

    UniProtKB/Swiss-Prot
    Q9R1I1, Q9WUE5
    UniProtKB/TrEMBL
    A0A0R4J1C9
    Conserved Domains (1) summary
    cl21551
    Location:44297
    Sulfotransfer_3; Sulfotransferase family
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