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    Fbxl13 F-box and leucine-rich repeat protein 13 [ Mus musculus (house mouse) ]

    Gene ID: 320118, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxl13provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 13provided by MGI
    Primary source
    MGI:MGI:2443416
    See related
    Ensembl:ENSMUSG00000048520 AllianceGenome:MGI:2443416
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921539K22Rik
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in centrosome; cytoplasm; and motile cilium. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in brain; lung; and reproductive system. Orthologous to human FBXL13 (F-box and leucine rich repeat protein 13). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 14.6) and ovary adult (RPKM 0.6) See more
    Orthologs
    NEW
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    Genomic context

    See Fbxl13 in Genome Data Viewer
    Location:
    5 A3; 5 9.83 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21688845..21850696, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (21483847..21645698, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene gamma-secretase activating protein Neighboring gene STARR-positive B cell enhancer ABC_E6308 Neighboring gene coiled-coil domain containing 146 Neighboring gene VISTA enhancer mm186 Neighboring gene STARR-positive B cell enhancer ABC_E6309 Neighboring gene predicted gene, 50626 Neighboring gene STARR-positive B cell enhancer ABC_E6310 Neighboring gene STARR-seq mESC enhancer starr_12565 Neighboring gene STARR-positive B cell enhancer ABC_E3562 Neighboring gene STARR-positive B cell enhancer ABC_E152 Neighboring gene fibrinogen-like protein 2 Neighboring gene family with sequence similarity 185, member A Neighboring gene STARR-seq mESC enhancer starr_12566 Neighboring gene STARR-seq mESC enhancer starr_12567 Neighboring gene leucine rich repeat containing 17 Neighboring gene STARR-seq mESC enhancer starr_12568 Neighboring gene STARR-seq mESC enhancer starr_12569 Neighboring gene predicted gene 6543 Neighboring gene STARR-positive B cell enhancer ABC_E11283 Neighboring gene protein archease pseudogene Neighboring gene STARR-seq mESC enhancer starr_12572 Neighboring gene armadillo repeat containing 10 Neighboring gene N-acyl phosphatidylethanolamine phospholipase D Neighboring gene microRNA 12197

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex  
    located_in centrosome  
    located_in cytoplasm  
    located_in motile cilium  

    General protein information

    Preferred Names
    F-box and leucine-rich repeat protein 13
    Names
    F-box/LRR-repeat protein 13
    dynein regulatory complex subunit 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199632.1NP_001186561.1  F-box and leucine-rich repeat protein 13 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer protein (isoform a).
      Source sequence(s)
      BB614373, BC145291, CO797010
      UniProtKB/TrEMBL
      B7ZNK1
      Conserved Domains (5) summary
      cd09293
      Location:536752
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:486523
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:537564
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240286
      F-box-like; F-box-like
      cl06673
      Location:5492
      Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases
    2. NM_177076.4NP_796050.2  F-box and leucine-rich repeat protein 13 isoform b

      See identical proteins and their annotated locations for NP_796050.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform b) is shorter when it is compared to isoform a.
      Source sequence(s)
      BB614373, BC145292, CO797010
      Consensus CDS
      CCDS51429.1
      UniProtKB/Swiss-Prot
      Q8CDE9, Q8CDU4
      UniProtKB/TrEMBL
      B7ZNK2
      Related
      ENSMUSP00000052716.5, ENSMUST00000051358.11
      Conserved Domains (5) summary
      cd09293
      Location:503719
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:453470
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:504531
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240286
      F-box-like; F-box-like
      cl06673
      Location:5492
      Extradiol_Dioxygenase_3A_like; Subunit A of Class III extradiol dioxygenases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      21688845..21850696 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535728.3XP_006535791.1  F-box and leucine-rich repeat protein 13 isoform X3

      UniProtKB/TrEMBL
      B7ZNK1
      Conserved Domains (4) summary
      cd09293
      Location:536752
      AMN1; Antagonist of mitotic exit network protein 1
      sd00033
      Location:486523
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:537564
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240284
      F-box-like
    2. XM_011249772.2XP_011248074.1  F-box and leucine-rich repeat protein 13 isoform X5

      Conserved Domains (2) summary
      cd09293
      Location:91223
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:5479
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. XM_011249771.4XP_011248073.1  F-box and leucine-rich repeat protein 13 isoform X4

      Conserved Domains (3) summary
      cd09293
      Location:211380
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:185211
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:145189
      F-box-like
    4. XM_011249770.4XP_011248072.1  F-box and leucine-rich repeat protein 13 isoform X2

      Conserved Domains (3) summary
      cd09293
      Location:306572
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:331356
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240284
      F-box-like
    5. XM_011249769.3XP_011248071.1  F-box and leucine-rich repeat protein 13 isoform X1

      Conserved Domains (3) summary
      cd09293
      Location:306475
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:280306
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:240284
      F-box-like
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