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PCGF2 polycomb group ring finger 2 [ Homo sapiens (human) ]

Gene ID: 7703, updated on 10-Dec-2024

Summary

Official Symbol
PCGF2provided by HGNC
Official Full Name
polycomb group ring finger 2provided by HGNC
Primary source
HGNC:HGNC:12929
See related
Ensembl:ENSG00000277258 MIM:600346; AllianceGenome:HGNC:12929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPFS; MEL-18; RNF110; ZNF144
Summary
The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues See more
Orthologs
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Genomic context

See PCGF2 in Genome Data Viewer
Location:
17q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (38733898..38749792, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (39596983..39611419, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (36890151..36904589, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MLLT6, PHD finger containing Neighboring gene uncharacterized LOC105371762 Neighboring gene microRNA 4726 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36881911-36882602 Neighboring gene control region 19 heart enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36887390-36887927 Neighboring gene RNA, 5S ribosomal pseudogene 440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36891176-36891703 Neighboring gene CDGSH iron sulfur domain 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36898365-36899265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36901628-36902393 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36902394-36903158 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:36904187-36904722 Neighboring gene uncharacterized LOC100287808 Neighboring gene tRNA-Asn (anticodon GTT) 2-5 Neighboring gene RNA, U6 small nuclear 866, pseudogene Neighboring gene proteasome 20S subunit beta 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Turnpenny-fry syndrome
MedGen: C5193060 OMIM: 618371 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC10545

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding  
enables metal ion binding  
enables promoter-specific chromatin binding  
enables protein binding PubMed 
Component Evidence Code Pubs
part_of PRC1 complex  
part_of PRC1 complex PubMed 
part_of PcG protein complex PubMed 
located_in chromatin PubMed 
located_in nuclear body  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in sex chromatin  

General protein information

Preferred Names
polycomb group RING finger protein 2
Names
DNA-binding protein Mel-18
ring finger protein 110
zinc finger protein 144

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369614.1NP_001356543.1  polycomb group RING finger protein 2

    Status: REVIEWED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS32638.1
    UniProtKB/Swiss-Prot
    A6NGD8, P35227
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  2. NM_001369615.1NP_001356544.1  polycomb group RING finger protein 2

    Status: REVIEWED

    Source sequence(s)
    AC006449, D13969
    Consensus CDS
    CCDS32638.1
    UniProtKB/Swiss-Prot
    A6NGD8, P35227
    Related
    ENSP00000478970.1, ENST00000611883.4
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  3. NM_007144.3NP_009075.1  polycomb group RING finger protein 2

    See identical proteins and their annotated locations for NP_009075.1

    Status: REVIEWED

    Source sequence(s)
    AC006449
    Consensus CDS
    CCDS32638.1
    UniProtKB/Swiss-Prot
    A6NGD8, P35227
    Related
    ENSP00000482815.1, ENST00000620225.5
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    38733898..38749792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047436660.1XP_047292616.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6NGD8, P35227
  2. XM_017025016.2XP_016880505.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6NGD8, P35227
    Conserved Domains (3) summary
    PLN02217
    Location:236328
    PLN02217; probable pectinesterase/pectinesterase inhibitor
    cd16736
    Location:1265
    RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins
    cd17164
    Location:130228
    RAWUL_PCGF2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 2 (PCGF2)
  3. XM_047436661.1XP_047292617.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6NGD8, P35227

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2769217..2783655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329331.1XP_054185306.1  polycomb group RING finger protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6NGD8, P35227

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    39596983..39611419 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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