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    LIPJ lipase family member J [ Homo sapiens (human) ]

    Gene ID: 142910, updated on 10-Dec-2024

    Summary

    Official Symbol
    LIPJprovided by HGNC
    Official Full Name
    lipase family member Jprovided by HGNC
    Primary source
    HGNC:HGNC:21773
    See related
    Ensembl:ENSG00000204022 MIM:613921; AllianceGenome:HGNC:21773
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIPL1; bA425M17.2
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be active in intracellular membrane-bounded organelle. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 1.7), thyroid (RPKM 0.3) and 20 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LIPJ in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88582907..88623184)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89466981..89507284)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90342664..90366733)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378416 Neighboring gene uncharacterized LOC101929727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3720 Neighboring gene renalase, FAD dependent amine oxidase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3721 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3722 Neighboring gene vomeronasal 1 receptor 55 pseudogene Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:90107282-90107945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3723 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3724 Neighboring gene ribosomal protein L7 pseudogene 34 Neighboring gene lipase F, gastric type Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, gamma pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    General gene information

    Clone Names

    • FLJ11218

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle  

    General protein information

    Preferred Names
    lipase member J
    Names
    lipase J
    lipase-like abhydrolase domain-containing protein 1
    lipase-like, ab-hydrolase domain containing 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010939.3NP_001010939.2  lipase member J isoform 1

      See identical proteins and their annotated locations for NP_001010939.2

      Status: VALIDATED

      Source sequence(s)
      AL139406
      Consensus CDS
      CCDS31240.1
      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Related
      ENSP00000361007.3, ENST00000371939.7
      Conserved Domains (3) summary
      pfam00561
      Location:48347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:366
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47209
      Abhydrolase_5; Alpha/beta hydrolase family
    2. NM_001394640.1NP_001381569.1  lipase member J isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL139406
      Conserved Domains (1) summary
      PLN02872
      Location:4310
      PLN02872; triacylglycerol lipase

    RNA

    1. NR_172141.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL139406

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88582907..88623184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717635.4XP_006717698.1  lipase member J isoform X1

      See identical proteins and their annotated locations for XP_006717698.1

      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Conserved Domains (3) summary
      pfam00561
      Location:48347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:366
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47209
      Abhydrolase_5; Alpha/beta hydrolase family
    2. XM_047424642.1XP_047280598.1  lipase member J isoform X2

    3. XM_047424643.1XP_047280599.1  lipase member J isoform X3

    4. XM_011539315.2XP_011537617.1  lipase member J isoform X1

      See identical proteins and their annotated locations for XP_011537617.1

      UniProtKB/Swiss-Prot
      A8MT98, Q0P671, Q5W064
      Conserved Domains (3) summary
      pfam00561
      Location:48347
      Abhydrolase_1; alpha/beta hydrolase fold
      pfam04083
      Location:366
      Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
      pfam12695
      Location:47209
      Abhydrolase_5; Alpha/beta hydrolase family
    5. XM_005269542.3XP_005269599.1  lipase member J isoform X4

      Conserved Domains (1) summary
      PLN02872
      Location:1246
      PLN02872; triacylglycerol lipase
    6. XM_011539319.1XP_011537621.1  lipase member J isoform X6

      See identical proteins and their annotated locations for XP_011537621.1

      Conserved Domains (1) summary
      PLN02872
      Location:57177
      PLN02872; triacylglycerol lipase
    7. XM_011539318.2XP_011537620.1  lipase member J isoform X5

      Conserved Domains (1) summary
      PLN02872
      Location:98218
      PLN02872; triacylglycerol lipase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89466981..89507284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364875.1XP_054220850.1  lipase member J isoform X1

    2. XM_054364877.1XP_054220852.1  lipase member J isoform X2

    3. XM_054364878.1XP_054220853.1  lipase member J isoform X3

    4. XM_054364876.1XP_054220851.1  lipase member J isoform X1

    5. XM_054364879.1XP_054220854.1  lipase member J isoform X4

    6. XM_054364881.1XP_054220856.1  lipase member J isoform X6

    7. XM_054364880.1XP_054220855.1  lipase member J isoform X5

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