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Scg5 secretogranin V [ Rattus norvegicus (Norway rat) ]

Gene ID: 25719, updated on 9-Dec-2024

Summary

Official Symbol
Scg5provided by RGD
Official Full Name
secretogranin Vprovided by RGD
Primary source
RGD:3669
See related
EnsemblRapid:ENSRNOG00000007542 AllianceGenome:RGD:3669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
7B2; Sgne1
Summary
Predicted to enable enzyme inhibitor activity and unfolded protein binding activity. Predicted to be involved in intracellular protein transport; peptide hormone processing; and regulation of hormone secretion. Predicted to be located in secretory granule. Predicted to be active in nucleus. Orthologous to human SCG5 (secretogranin V). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 1374.1) See more
Orthologs
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Genomic context

See Scg5 in Genome Data Viewer
Location:
3q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (120998420..121042881, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (100544101..100588558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (105235065..105279475, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene sorbitol dehydrogenase, pseudogene 5 Neighboring gene gremlin 1, DAN family BMP antagonist Neighboring gene Rho GTPase activating protein 11A Neighboring gene uncharacterized LOC103691860 Neighboring gene uncharacterized LOC120101628 Neighboring gene gap junction protein, delta 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme inhibitor activity  
enables enzyme inhibitor activity  
enables enzyme inhibitor activity  
enables enzyme regulator activity  
enables protein binding PubMed 
enables unfolded protein binding  
enables unfolded protein binding  
enables unfolded protein binding  
Process Evidence Code Pubs
involved_in intracellular protein transport  
involved_in intracellular protein transport  
involved_in intracellular protein transport  
involved_in neuropeptide signaling pathway  
involved_in peptide hormone processing  
involved_in peptide hormone processing  
involved_in peptide hormone processing  
involved_in regulation of hormone secretion  
involved_in regulation of hormone secretion  
involved_in regulation of hormone secretion  
involved_in regulation of hormone secretion  
Component Evidence Code Pubs
located_in extracellular region  
located_in nucleus  
is_active_in nucleus  
located_in secretory granule  
located_in secretory granule  
located_in secretory granule  

General protein information

Preferred Names
neuroendocrine protein 7B2
Names
Secretory granule neuroendocrine, protein 1 (7B2 protein)
secretogranin V (7B2 protein)
secretogranin-5
secretory granule endocrine protein I
secretory granule neuroendocrine protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013175.4NP_037307.2  neuroendocrine protein 7B2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P27682
    UniProtKB/TrEMBL
    A6HP67, G3V714
    Related
    ENSRNOP00000010679.5, ENSRNOT00000010679.8
    Conserved Domains (1) summary
    pfam05281
    Location:22197
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    120998420..121042881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234701.5XP_006234763.1  neuroendocrine protein 7B2 isoform X1

    UniProtKB/Swiss-Prot
    P27682
    Conserved Domains (1) summary
    pfam05281
    Location:22196
    Secretogranin_V; Neuroendocrine protein 7B2 precursor (Secretogranin V)
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