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Rab28 RAB28, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 117049, updated on 9-Dec-2024

Summary

Official Symbol
Rab28provided by RGD
Official Full Name
RAB28, member RAS oncogene familyprovided by RGD
Primary source
RGD:620891
See related
EnsemblRapid:ENSRNOG00000017074 AllianceGenome:RGD:620891
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GTP binding activity. Predicted to be involved in intracellular protein transport. Located in ciliary basal body and ciliary rootlet. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 170.7), Heart (RPKM 161.4) and 9 other tissues See more
Orthologs
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Genomic context

See Rab28 in Genome Data Viewer
Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (73458386..73535367)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (69245846..69322968)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (73888968..73963209)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550431 Neighboring gene uncharacterized LOC120096626 Neighboring gene RNA polymerase III subunit F, pseudogene 1 Neighboring gene clusterin associated protein 1, pseudogene 2 Neighboring gene developmental pluripotency-associated protein 3-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding  
enables GDP binding  
enables GTP binding PubMed 
enables GTP binding  
enables GTP binding  
enables GTP binding  
enables GTPase activity  
enables GTPase activity  
enables GTPase activity PubMed 
Component Evidence Code Pubs
located_in ciliary basal body PubMed 
located_in ciliary rootlet PubMed 
located_in cilium  
located_in cytoplasm  
located_in cytoskeleton  
is_active_in endomembrane system  
located_in plasma membrane  

General protein information

Preferred Names
ras-related protein Rab-28
Names
rab-26
NP_446430.1
XP_008768417.1
XP_008768418.1
XP_008768419.1
XP_008768420.1
XP_017454543.1
XP_063128875.1
XP_063128876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053978.1NP_446430.1  ras-related protein Rab-28

    See identical proteins and their annotated locations for NP_446430.1

    Status: PROVISIONAL

    Source sequence(s)
    X78606
    UniProtKB/Swiss-Prot
    P51158
    UniProtKB/TrEMBL
    A6IJR0, A6IJR3
    Conserved Domains (1) summary
    cd04109
    Location:13221
    Rab28; Rab GTPase family 28 (Rab28)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    73458386..73535367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770196.3XP_008768418.1  ras-related protein Rab-28 isoform X1

    See identical proteins and their annotated locations for XP_008768418.1

    UniProtKB/TrEMBL
    A6IJR0, Q6IN03
    Conserved Domains (1) summary
    cd04109
    Location:13220
    Rab28; Rab GTPase family 28 (Rab28)
  2. XM_017599054.3XP_017454543.1  ras-related protein Rab-28 isoform X5

    UniProtKB/TrEMBL
    A6IJR0, A6IJR1
    Conserved Domains (2) summary
    smart00175
    Location:13178
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:13191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_008770198.3XP_008768420.1  ras-related protein Rab-28 isoform X4

    See identical proteins and their annotated locations for XP_008768420.1

    UniProtKB/TrEMBL
    A0A8I5ZQN9, A6IJQ9, A6IJR0
    Conserved Domains (1) summary
    cl38936
    Location:13193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_008770195.3XP_008768417.1  ras-related protein Rab-28 isoform X1

    See identical proteins and their annotated locations for XP_008768417.1

    UniProtKB/TrEMBL
    A6IJR0, Q6IN03
    Related
    ENSRNOP00000050260.2, ENSRNOT00000041310.6
    Conserved Domains (1) summary
    cd04109
    Location:13220
    Rab28; Rab GTPase family 28 (Rab28)
  5. XM_063272805.1XP_063128875.1  ras-related protein Rab-28 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GGV5
    Related
    ENSRNOP00000080796.2, ENSRNOT00000117951.2
  6. XM_008770197.4XP_008768419.1  ras-related protein Rab-28 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GGV5
    Related
    ENSRNOP00000071725.2, ENSRNOT00000081033.3
    Conserved Domains (2) summary
    smart00175
    Location:16170
    RAB; Rab subfamily of small GTPases
    cd04109
    Location:16213
    Rab28; Rab GTPase family 28 (Rab28)
  7. XM_063272806.1XP_063128876.1  ras-related protein Rab-28 isoform X6

    UniProtKB/TrEMBL
    A6IJR0

RNA

  1. XR_005492875.2 RNA Sequence

  2. XR_005492878.2 RNA Sequence

  3. XR_005492874.2 RNA Sequence

  4. XR_005492877.2 RNA Sequence

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