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Hars2 histidyl-tRNA synthetase 2 [ Mus musculus (house mouse) ]

Gene ID: 70791, updated on 9-Dec-2024

Summary

Official Symbol
Hars2provided by MGI
Official Full Name
histidyl-tRNA synthetase 2provided by MGI
Primary source
MGI:MGI:1918041
See related
Ensembl:ENSMUSG00000019143 AllianceGenome:MGI:1918041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HO3; HARSR; Harsl; 4631412B19Rik
Summary
This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of histidine to tRNA molecules. Mutations in a similar gene in human have been associated with Perrault syndrome 2 (PRLTS2). [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.8), CNS E14 (RPKM 10.4) and 28 other tissues See more
Orthologs
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Genomic context

See Hars2 in Genome Data Viewer
Location:
18 B2; 18 19.46 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36916257..36925615)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36783202..36792562)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E617 Neighboring gene IK cytokine Neighboring gene WD repeat domain 55 Neighboring gene DND microRNA-mediated repression inhibitor 1 Neighboring gene histidyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E8710 Neighboring gene STARR-positive B cell enhancer ABC_E3227 Neighboring gene zinc finger, matrin type 2 Neighboring gene STARR-positive B cell enhancer ABC_E1207 Neighboring gene vault RNA component 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding  
enables RNA binding  
enables histidine-tRNA ligase activity  
enables histidine-tRNA ligase activity  
enables histidine-tRNA ligase activity  
enables identical protein binding  
enables identical protein binding  
enables identical protein binding  
Process Evidence Code Pubs
involved_in histidyl-tRNA aminoacylation  
involved_in histidyl-tRNA aminoacylation  
involved_in histidyl-tRNA aminoacylation  
Component Evidence Code Pubs
is_active_in cytosol  
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion  

General protein information

Preferred Names
histidine--tRNA ligase, mitochondrial
Names
hisRS
histidyl-tRNA synthetase 2, mitochondrial (putative)
probable histidine--tRNA ligase, mitochondrial
probable histidyl-tRNA synthetase, mitochondrial
NP_001292556.1
NP_001347850.1
NP_542367.1
XP_011245301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305627.1NP_001292556.1  histidine--tRNA ligase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_001292556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC027740, AI593507, AK077621
    Consensus CDS
    CCDS84376.1
    UniProtKB/TrEMBL
    G5E823
    Related
    ENSMUSP00000019287.9, ENSMUST00000019287.9
    Conserved Domains (3) summary
    COG0124
    Location:56422
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:69243
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:327418
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...
  2. NM_001360921.1NP_001347850.1  histidine--tRNA ligase, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the coding region, lacks an exon in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC027740
    Conserved Domains (1) summary
    cl28413
    Location:2330
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
  3. NM_080636.2NP_542367.1  histidine--tRNA ligase, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_542367.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC027740, AI593507, AK077621
    Consensus CDS
    CCDS29165.1
    UniProtKB/Swiss-Prot
    Q99KK9
    Related
    ENSMUSP00000117231.2, ENSMUST00000152954.8
    Conserved Domains (3) summary
    COG0124
    Location:56503
    HisS; Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00773
    Location:69394
    HisRS-like_core; Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent ...
    cd00859
    Location:408499
    HisRS_anticodon; HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36916257..36925615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246999.3XP_011245301.1  histidine--tRNA ligase, mitochondrial isoform X1

    Conserved Domains (1) summary
    PLN02972
    Location:1363
    PLN02972; Histidyl-tRNA synthetase

RNA

  1. XR_386015.4 RNA Sequence

  2. XR_003952541.2 RNA Sequence

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