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TMEM245 transmembrane protein 245 [ Homo sapiens (human) ]

Gene ID: 23731, updated on 10-Dec-2024

Summary

Official Symbol
TMEM245provided by HGNC
Official Full Name
transmembrane protein 245provided by HGNC
Primary source
HGNC:HGNC:1363
See related
Ensembl:ENSG00000106771 MIM:620252; AllianceGenome:HGNC:1363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG2; CG-2; C9orf5
Summary
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in thyroid (RPKM 48.4), adrenal (RPKM 29.0) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM245 in Genome Data Viewer
Location:
9q31.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (109015135..109119947, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (121184210..121289014, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (111777415..111882227, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20160 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:111713956-111715155 Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha like 1 Neighboring gene uncharacterized LOC105376216 Neighboring gene RNA, 5.8S ribosomal pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:111774967-111775470 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:111798078-111799277 Neighboring gene microRNA 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20163 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20164 Neighboring gene ferric chelate reductase 1 like Neighboring gene Sharpr-MPRA regulatory region 1434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:111947797-111948296 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene RNA, U6 small nuclear 984, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Phenotypes

EBI GWAS Catalog

Description
BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.
EBI GWAS Catalog
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
EBI GWAS Catalog
Whole genome association scan for genetic polymorphisms influencing information processing speed.
EBI GWAS Catalog

Interactions

General gene information

Clone Names

  • FLJ23668, FLJ33224

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane PubMed 

General protein information

Preferred Names
transmembrane protein 245
Names
protein CG-2
transmembrane protein C9orf5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032012.4NP_114401.2  transmembrane protein 245

    See identical proteins and their annotated locations for NP_114401.2

    Status: VALIDATED

    Source sequence(s)
    AL354797, AL358815, AL556162, BC014248, BE675782, BM817899, BP351493, BP360669, DC341553
    Consensus CDS
    CCDS43858.1
    UniProtKB/Swiss-Prot
    B4DSW7, Q5JTQ5, Q5SS43, Q6ZME3, Q8NDJ5, Q96CG6, Q9H330
    Related
    ENSP00000363714.3, ENST00000374586.8
    Conserved Domains (1) summary
    cl00465
    Location:594840
    AI-2E_transport; AI-2E family transporter

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    109015135..109119947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423140.1XP_047279096.1  transmembrane protein 245 isoform X7

  2. XM_011518449.3XP_011516751.1  transmembrane protein 245 isoform X4

    Conserved Domains (1) summary
    cl00465
    Location:555801
    UPF0118; Domain of unknown function DUF20
  3. XM_047423142.1XP_047279098.1  transmembrane protein 245 isoform X10

  4. XM_017014572.2XP_016870061.1  transmembrane protein 245 isoform X9

  5. XM_011518452.3XP_011516754.1  transmembrane protein 245 isoform X8

    Conserved Domains (1) summary
    cl00465
    Location:516762
    UPF0118; Domain of unknown function DUF20
  6. XM_047423139.1XP_047279095.1  transmembrane protein 245 isoform X6

  7. XM_017014571.2XP_016870060.1  transmembrane protein 245 isoform X3

  8. XM_011518446.3XP_011516748.1  transmembrane protein 245 isoform X1

    Conserved Domains (1) summary
    cl00465
    Location:593839
    UPF0118; Domain of unknown function DUF20
  9. XM_011518451.2XP_011516753.1  transmembrane protein 245 isoform X5

    Conserved Domains (1) summary
    cl00465
    Location:551797
    UPF0118; Domain of unknown function DUF20
  10. XM_011518447.2XP_011516749.1  transmembrane protein 245 isoform X2

    UniProtKB/TrEMBL
    H7C0G1
    Related
    ENSP00000394798.3, ENST00000413712.7
    Conserved Domains (1) summary
    cl00465
    Location:586832
    UPF0118; Domain of unknown function DUF20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    121184210..121289014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362596.1XP_054218571.1  transmembrane protein 245 isoform X7

  2. XM_054362593.1XP_054218568.1  transmembrane protein 245 isoform X4

  3. XM_054362599.1XP_054218574.1  transmembrane protein 245 isoform X10

  4. XM_054362598.1XP_054218573.1  transmembrane protein 245 isoform X9

  5. XM_054362597.1XP_054218572.1  transmembrane protein 245 isoform X8

  6. XM_054362595.1XP_054218570.1  transmembrane protein 245 isoform X6

  7. XM_054362592.1XP_054218567.1  transmembrane protein 245 isoform X3

  8. XM_054362590.1XP_054218565.1  transmembrane protein 245 isoform X1

  9. XM_054362594.1XP_054218569.1  transmembrane protein 245 isoform X5

  10. XM_054362591.1XP_054218566.1  transmembrane protein 245 isoform X2

    UniProtKB/TrEMBL
    H7C0G1

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