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Sirt5 sirtuin 5 [ Mus musculus (house mouse) ]

Gene ID: 68346, updated on 9-Dec-2024

Summary

Official Symbol
Sirt5provided by MGI
Official Full Name
sirtuin 5provided by MGI
Primary source
MGI:MGI:1915596
See related
Ensembl:ENSMUSG00000054021 AllianceGenome:MGI:1915596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610012J09Rik; 1500032M05Rik
Summary
Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; heart; oocyte; palatal shelf; and sensory organ. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in heart adult (RPKM 3.8), bladder adult (RPKM 2.9) and 28 other tissues See more
Orthologs
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Genomic context

See Sirt5 in Genome Data Viewer
Location:
13 A4; 13 21.6 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43518849..43549073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43365389..43395203)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52047 Neighboring gene predicted gene, 53796 Neighboring gene RAN binding protein 9 Neighboring gene nucleolar protein 7 Neighboring gene predicted gene, 26064

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ binding  
enables NAD+ binding  
enables NAD+ binding  
enables NAD-dependent protein lysine deacetylase activity  
enables histone deacetylase activity, NAD-dependent  
enables protein binding PubMed 
enables protein-glutaryllysine deglutarylase activity  
enables protein-glutaryllysine deglutarylase activity PubMed 
enables protein-glutaryllysine deglutarylase activity  
enables protein-malonyllysine demalonylase activity  
enables protein-malonyllysine demalonylase activity PubMed 
enables protein-malonyllysine demalonylase activity PubMed 
enables protein-malonyllysine demalonylase activity  
enables protein-succinyllysine desuccinylase activity  
enables protein-succinyllysine desuccinylase activity PubMed 
enables protein-succinyllysine desuccinylase activity PubMed 
enables protein-succinyllysine desuccinylase activity  
enables zinc ion binding  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process  
involved_in negative regulation of reactive oxygen species metabolic process  
involved_in peptidyl-lysine demalonylation PubMed 
involved_in peptidyl-lysine demalonylation  
acts_upstream_of_or_within peptidyl-lysine desuccinylation PubMed 
involved_in peptidyl-lysine desuccinylation PubMed 
involved_in peptidyl-lysine desuccinylation  
involved_in protein deacetylation  
NOT involved_in protein deacetylation  
involved_in protein deglutarylation PubMed 
involved_in protein deglutarylation  
involved_in protein demalonylation PubMed 
involved_in protein demalonylation  
involved_in protein desuccinylation PubMed 
involved_in protein desuccinylation PubMed 
involved_in protein desuccinylation  
involved_in regulation of ketone biosynthetic process PubMed 
acts_upstream_of_or_within regulation of succinate dehydrogenase activity PubMed 
acts_upstream_of_or_within response to ischemia PubMed 
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol PubMed 
located_in cytosol  
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial intermembrane space  
located_in mitochondrial intermembrane space  
is_active_in mitochondrial matrix  
located_in mitochondrial matrix  
located_in mitochondrial matrix  
located_in mitochondrion PubMed 
is_active_in mitochondrion  
located_in mitochondrion PubMed 
is_active_in mitochondrion PubMed 
located_in mitochondrion  
located_in mitochondrion  
is_active_in nucleus  
located_in nucleus PubMed 

General protein information

Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
NP_849179.1
XP_006517014.1
XP_006517015.1
XP_006517016.1
XP_006517017.1
XP_011242714.1
XP_011242715.1
XP_030103247.1
XP_030103248.1
XP_030103249.1
XP_030103250.1
XP_036014035.1
XP_036014036.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178848.3NP_849179.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial

    See identical proteins and their annotated locations for NP_849179.1

    Status: PROVISIONAL

    Source sequence(s)
    AC132121
    Consensus CDS
    CCDS26478.1
    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Related
    ENSMUSP00000152796.2, ENSMUST00000223194.2
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    43518849..43549073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516951.3XP_006517014.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517014.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  2. XM_006516954.2XP_006517017.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:4181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. XM_036158143.1XP_036014036.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:4179
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  4. XM_030247387.2XP_030103247.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Related
    ENSMUSP00000152740.2, ENSMUST00000220576.2
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  5. XM_036158142.1XP_036014035.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00195
    Location:4181
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  6. XM_006516953.3XP_006517016.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517016.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Related
    ENSMUSP00000152526.2, ENSMUST00000221515.2
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  7. XM_006516952.5XP_006517015.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006517015.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  8. XM_030247390.2XP_030103250.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00195
    Location:4179
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  9. XM_030247388.2XP_030103248.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  10. XM_011244413.3XP_011242715.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242715.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  11. XM_030247389.2XP_030103249.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8K2C6
    UniProtKB/TrEMBL
    A0A1Y7VJY8
    Conserved Domains (1) summary
    cd01412
    Location:51301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
  12. XM_011244412.3XP_011242714.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011242714.1

    UniProtKB/TrEMBL
    A0A1Y7VJY8, A0A1Y7VM56
    Conserved Domains (1) summary
    cd01412
    Location:51289
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...
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