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Tbh Tyramine beta hydroxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31718, updated on 17-Dec-2024

Summary

Official Symbol
Tbhprovided by FlyBase
Official Full Name
Tyramine beta hydroxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010329
Locus tag
Dmel_CG1543
See related
AllianceGenome:FB:FBgn0010329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1543; Dbh; DBH; Dmel\CG1543; T beta h; tbetah; Tbetah; TbetaH; TBetah; TBetaH; TbetaM; tbh; TbH; TBh; TBH
Summary
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen. Involved in several processes, including behavioral response to ethanol; inter-male aggressive behavior; and learning or memory. Predicted to be active in extracellular space and secretory granule membrane. Is expressed in several structures, including adult brain; adult central complex; octopaminergic neurons; synaptic neuropil domain; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; dopamine beta-hydroxylase deficiency; hypertension; and migraine with aura. Orthologous to human DBH (dopamine beta-hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Tbh in Genome Data Viewer
Location:
7D2-7D2; 1-22 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7995697..8027394)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7889730..7921427)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45620 Neighboring gene swiss cheese Neighboring gene singed Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene female sterile (1) homeotic

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in aggressive behavior PubMed 
involved_in behavioral response to ethanol PubMed 
involved_in behavioral response to ethanol PubMed 
acts_upstream_of behavioral response to pain PubMed 
involved_in dopamine catabolic process  
involved_in flight behavior PubMed 
involved_in inter-male aggressive behavior PubMed 
involved_in larval locomotory behavior PubMed 
involved_in learning PubMed 
involved_in locomotion PubMed 
involved_in male courtship behavior PubMed 
involved_in mating behavior, sex discrimination PubMed 
involved_in memory PubMed 
involved_in norepinephrine biosynthetic process  
involved_in octopamine biosynthetic process  
involved_in octopamine biosynthetic process PubMed 
involved_in octopamine signaling pathway PubMed 
involved_in ovulation PubMed 
involved_in regulation of behavior PubMed 
involved_in regulation of forward locomotion PubMed 
Component Evidence Code Pubs
is_active_in extracellular space  
is_active_in secretory granule membrane  

General protein information

Preferred Names
tyramine beta hydroxylase
Names
CG1543-PB
CG1543-PC
Tbh-PB
Tbh-PC
Tyrosine-beta-hydroxylase
dopamine beta hydroxylase
tyramine beta-hydroxylase
tyramine beta-monooxygenase
tyramine betahydroxylase
tyramine-beta-hydroxylase
tyroside beta-hydroxylase
tyrosine beta hydroxylase
NP_001284996.1
NP_788884.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    7995697..8027394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176711.3 → NP_788884.1  tyramine beta hydroxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788884.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1EC33, Q24549, Q86B61
    UniProtKB/TrEMBL
    X2JIW9
    Related
    FBpp0089042
    Conserved Domains (3) summary
    pfam01082
    Location:264 → 389
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03351
    Location:102 → 220
    DOMON; DOMON domain
    pfam03712
    Location:410 → 565
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
  2. NM_001298067.1 → NP_001284996.1  tyramine beta hydroxylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284996.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1EC33, Q24549, Q86B61
    UniProtKB/TrEMBL
    X2JIW9
    Conserved Domains (3) summary
    pfam01082
    Location:264 → 389
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03351
    Location:102 → 220
    DOMON; DOMON domain
    pfam03712
    Location:410 → 565
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
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