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C1orf116 chromosome 1 open reading frame 116 [ Homo sapiens (human) ]

Gene ID: 79098, updated on 10-Dec-2024

Summary

Official Symbol
C1orf116provided by HGNC
Official Full Name
chromosome 1 open reading frame 116provided by HGNC
Primary source
HGNC:HGNC:28667
See related
Ensembl:ENSG00000182795 MIM:611680; AllianceGenome:HGNC:28667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SARG
Summary
Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in lung (RPKM 46.8), esophagus (RPKM 46.0) and 10 other tissues See more
Orthologs
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Genomic context

See C1orf116 in Genome Data Viewer
Location:
1q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (207018522..207032756, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206283713..206297960, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207191867..207206101, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207134913-207136112 Neighboring gene Fc alpha and mu receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2438 Neighboring gene tRNA-Pro (anticodon TGG) 5-1 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207192892-207194091 Neighboring gene small nucleolar RNA U13 Neighboring gene Sharpr-MPRA regulatory region 4428 Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207224117-207224687 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:207225911-207226550 Neighboring gene YOD1 deubiquitinase

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Interactions

General gene information

Clone Names

  • MGC2742, MGC4309, FLJ36507, DKFZp666H2010

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytosol  
located_in extracellular exosome PubMed 
located_in plasma membrane  

General protein information

Preferred Names
specifically androgen-regulated gene protein
Names
specifically androgen-regulated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083924.2NP_001077393.1  specifically androgen-regulated gene protein isoform 2

    See identical proteins and their annotated locations for NP_001077393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon at its 5' end, compared to variant 1, producing a distinct 5' UTR and causing translation initiation at a downstream AUG. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC098935, BG150416, DA859157
    Consensus CDS
    CCDS44306.1
    UniProtKB/Swiss-Prot
    Q9BW04
    Related
    ENSP00000436862.1, ENST00000461135.2
    Conserved Domains (1) summary
    pfam15385
    Location:1355
    SARG; Specifically androgen-regulated gene protein
  2. NM_023938.6NP_076427.2  specifically androgen-regulated gene protein isoform 1

    See identical proteins and their annotated locations for NP_076427.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098935, BC000765, BG150416, DA859157
    Consensus CDS
    CCDS1475.1
    UniProtKB/Swiss-Prot
    C9JV41, Q658X3, Q9BW04
    Related
    ENSP00000352447.5, ENST00000359470.6
    Conserved Domains (1) summary
    pfam15385
    Location:40601
    SARG; Specifically androgen-regulated gene protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    207018522..207032756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509973.3XP_011508275.1  specifically androgen-regulated gene protein isoform X2

    See identical proteins and their annotated locations for XP_011508275.1

    UniProtKB/Swiss-Prot
    Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:1355
    SARG; Specifically androgen-regulated gene protein
  2. XM_006711530.2XP_006711593.1  specifically androgen-regulated gene protein isoform X1

    See identical proteins and their annotated locations for XP_006711593.1

    UniProtKB/Swiss-Prot
    C9JV41, Q658X3, Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:40601
    SARG; Specifically androgen-regulated gene protein
  3. XM_005273259.2XP_005273316.1  specifically androgen-regulated gene protein isoform X2

    See identical proteins and their annotated locations for XP_005273316.1

    UniProtKB/Swiss-Prot
    Q9BW04
    Conserved Domains (1) summary
    pfam15385
    Location:1355
    SARG; Specifically androgen-regulated gene protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    206283713..206297960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338684.1XP_054194659.1  specifically androgen-regulated gene protein isoform X1

  2. XM_054338686.1XP_054194661.1  specifically androgen-regulated gene protein isoform X2

  3. XM_054338685.1XP_054194660.1  specifically androgen-regulated gene protein isoform X2

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