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    AKAP11 A-kinase anchoring protein 11 [ Homo sapiens (human) ]

    Gene ID: 11215, updated on 10-Dec-2024

    Summary

    Official Symbol
    AKAP11provided by HGNC
    Official Full Name
    A-kinase anchoring protein 11provided by HGNC
    Primary source
    HGNC:HGNC:369
    See related
    Ensembl:ENSG00000023516 MIM:604696; AllianceGenome:HGNC:369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRKA11; AKAP-11; AKAP220; PPP1R44
    Summary
    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed at high levels throughout spermatogenesis and in mature sperm. It binds the RI and RII subunits of PKA in testis. It may serve a function in cell cycle control of both somatic cells and germ cells in addition to its putative role in spermatogenesis and sperm function. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 22.2), testis (RPKM 15.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See AKAP11 in Genome Data Viewer
    Location:
    13q14.11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (42271477..42323261)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (41491099..41543005)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (42846288..42897397)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase eta Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 11 Neighboring gene CRISPRi-validated cis-regulatory element chr13.544 Neighboring gene CRISPRi-validated cis-regulatory element chr13.545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7639 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5298 Neighboring gene NANOG hESC enhancer GRCh37_chr13:42858188-42858689 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:42872570-42873769 Neighboring gene fumarate hydratase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7641 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:42933453-42934652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7644 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7645 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7646 Neighboring gene fatty acid binding protein 3 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5300 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:42979722-42980921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7649 Neighboring gene long intergenic non-protein coding RNA 2341

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
    EBI GWAS Catalog
    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ11304, KIAA0629, DKFZp781I12161

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables protein kinase A binding  
    enables protein kinase A regulatory subunit binding  
    enables protein phosphatase 1 binding PubMed 
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization  
    involved_in intracellular signal transduction PubMed 
    involved_in protein localization  
    involved_in protein localization to endosome  
    involved_in renal water homeostasis  
    Component Evidence Code Pubs
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in nucleolus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    A-kinase anchor protein 11
    Names
    A kinase (PRKA) anchor protein 11
    A-kinase anchor protein 220 kDa
    A-kinase anchoring protein, 220kDa
    a kinase anchor protein 220 kDa
    protein kinase A anchoring protein 11
    protein phosphatase 1, regulatory subunit 44

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016248.4NP_057332.1  A-kinase anchor protein 11

      See identical proteins and their annotated locations for NP_057332.1

      Status: REVIEWED

      Source sequence(s)
      AF176555, AL136527, BE670178, BE694434, DA780016
      Consensus CDS
      CCDS9383.1
      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Related
      ENSP00000025301.2, ENST00000025301.4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      42271477..42323261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011534904.2XP_011533206.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533206.1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    2. XM_047430073.1XP_047286029.1  A-kinase anchor protein 11 isoform X2

    3. XM_047430077.1XP_047286033.1  A-kinase anchor protein 11 isoform X3

    4. XM_011534906.3XP_011533208.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533208.1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    5. XM_047430075.1XP_047286031.1  A-kinase anchor protein 11 isoform X2

    6. XM_017020383.2XP_016875872.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    7. XM_011534903.3XP_011533205.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533205.1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    8. XM_047430072.1XP_047286028.1  A-kinase anchor protein 11 isoform X2

    9. XM_047430076.1XP_047286032.1  A-kinase anchor protein 11 isoform X3

    10. XM_047430079.1XP_047286035.1  A-kinase anchor protein 11 isoform X4

    11. XM_017020381.3XP_016875870.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    12. XM_005266249.4XP_005266306.1  A-kinase anchor protein 11 isoform X5

    13. XM_005266247.2XP_005266304.1  A-kinase anchor protein 11 isoform X2

      Conserved Domains (1) summary
      cl14906
      Location:16551872
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    14. XM_005266250.4XP_005266307.1  A-kinase anchor protein 11 isoform X6

    15. XM_005266248.4XP_005266305.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    16. XM_047430078.1XP_047286034.1  A-kinase anchor protein 11 isoform X4

    17. XM_011534905.2XP_011533207.1  A-kinase anchor protein 11 isoform X1

      See identical proteins and their annotated locations for XP_011533207.1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
      Conserved Domains (1) summary
      cl14906
      Location:18041900
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    18. XM_047430074.1XP_047286030.1  A-kinase anchor protein 11 isoform X2

    19. XM_017020382.2XP_016875871.1  A-kinase anchor protein 11 isoform X3

      Conserved Domains (1) summary
      cl14906
      Location:17591855
      AKAP_110; A-kinase anchor protein 110 kDa (AKAP 110)
    20. XM_047430080.1XP_047286036.1  A-kinase anchor protein 11 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      41491099..41543005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374067.1XP_054230042.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
    2. XM_054374066.1XP_054230041.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
    3. XM_054374072.1XP_054230047.1  A-kinase anchor protein 11 isoform X2

    4. XM_054374070.1XP_054230045.1  A-kinase anchor protein 11 isoform X2

    5. XM_054374076.1XP_054230051.1  A-kinase anchor protein 11 isoform X3

    6. XM_054374077.1XP_054230052.1  A-kinase anchor protein 11 isoform X3

    7. XM_054374063.1XP_054230038.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
    8. XM_054374069.1XP_054230044.1  A-kinase anchor protein 11 isoform X2

    9. XM_054374079.1XP_054230054.1  A-kinase anchor protein 11 isoform X4

    10. XM_054374074.1XP_054230049.1  A-kinase anchor protein 11 isoform X3

    11. XM_054374081.1XP_054230056.1  A-kinase anchor protein 11 isoform X5

    12. XM_054374068.1XP_054230043.1  A-kinase anchor protein 11 isoform X2

    13. XM_054374082.1XP_054230057.1  A-kinase anchor protein 11 isoform X6

    14. XM_054374073.1XP_054230048.1  A-kinase anchor protein 11 isoform X3

    15. XM_054374078.1XP_054230053.1  A-kinase anchor protein 11 isoform X4

    16. XM_054374064.1XP_054230039.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4
    17. XM_054374071.1XP_054230046.1  A-kinase anchor protein 11 isoform X2

    18. XM_054374075.1XP_054230050.1  A-kinase anchor protein 11 isoform X3

    19. XM_054374080.1XP_054230055.1  A-kinase anchor protein 11 isoform X4

    20. XM_054374065.1XP_054230040.1  A-kinase anchor protein 11 isoform X1

      UniProtKB/Swiss-Prot
      O75124, Q9NUK7, Q9UKA4

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