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Nacc1 nucleus accumbens associated 1, BEN and BTB (POZ) domain containing [ Mus musculus (house mouse) ]

Gene ID: 66830, updated on 9-Dec-2024

Summary

Official Symbol
Nacc1provided by MGI
Official Full Name
nucleus accumbens associated 1, BEN and BTB (POZ) domain containingprovided by MGI
Primary source
MGI:MGI:1914080
See related
Ensembl:ENSMUSG00000001910 AllianceGenome:MGI:1914080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nac1; Btbd14b; 2010001H03Rik; 4930511N13Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of DNA-templated transcription; positive regulation of cell population proliferation; and regulation of transcription by RNA polymerase II. Predicted to be located in cell junction and nucleoplasm. Is expressed in several structures, including blastocyst; cartilage; gut epithelium; nervous system; and otocyst. Orthologous to human NACC1 (nucleus accumbens associated 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 78.7), thymus adult (RPKM 50.9) and 28 other tissues See more
Orthologs
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Genomic context

See Nacc1 in Genome Data Viewer
Location:
8 C3; 8 41.02 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85397106..85414528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84670477..84687862, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22134 Neighboring gene STARR-positive B cell enhancer ABC_E5025 Neighboring gene STARR-positive B cell enhancer ABC_E883 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 26664 Neighboring gene immediate early response 2 Neighboring gene tRNA methyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E6667 Neighboring gene STARR-positive B cell enhancer ABC_E5026 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87228416-87228525 Neighboring gene lymphoblastomic leukemia 1 Neighboring gene nuclear factor I/X Neighboring gene RIKEN cDNA G430095P16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cell junction  
located_in cell junction  
located_in cytoplasm  
located_in intracellular membrane-bounded organelle  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus  
located_in nucleus  

General protein information

Preferred Names
nucleus accumbens-associated protein 1
Names
BTB (POZ) domain containing 14B
BTB/POZ domain-containing protein 14B
NAC-1
transcriptional repressor NAC1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025788.3NP_080064.3  nucleus accumbens-associated protein 1

    See identical proteins and their annotated locations for NP_080064.3

    Status: VALIDATED

    Source sequence(s)
    BC054800
    Consensus CDS
    CCDS22475.1
    UniProtKB/Swiss-Prot
    Q7TSZ8, Q80X97, Q9CZ72
    Related
    ENSMUSP00000001975.5, ENSMUST00000001975.6
    Conserved Domains (2) summary
    smart01025
    Location:382460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85397106..85414528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531295.5XP_006531358.1  nucleus accumbens-associated protein 1 isoform X2

    Conserved Domains (2) summary
    smart01025
    Location:355433
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
  2. XM_006531293.5XP_006531356.1  nucleus accumbens-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006531356.1

    UniProtKB/Swiss-Prot
    Q7TSZ8, Q80X97, Q9CZ72
    Conserved Domains (2) summary
    smart01025
    Location:382460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
  3. XM_006531294.5XP_006531357.1  nucleus accumbens-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006531357.1

    UniProtKB/Swiss-Prot
    Q7TSZ8, Q80X97, Q9CZ72
    Conserved Domains (2) summary
    smart01025
    Location:382460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
  4. XM_036154244.1XP_036010137.1  nucleus accumbens-associated protein 1 isoform X2

    Conserved Domains (2) summary
    smart01025
    Location:355433
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
  5. XM_006531292.4XP_006531355.1  nucleus accumbens-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006531355.1

    UniProtKB/Swiss-Prot
    Q7TSZ8, Q80X97, Q9CZ72
    Conserved Domains (2) summary
    smart01025
    Location:382460
    BEN; The BEN domain is found in diverse animal proteins
    cd18290
    Location:3125
    BTB_POZ_BTBD14B_NAC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1)
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