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SUSD6 sushi domain containing 6 [ Homo sapiens (human) ]

Gene ID: 9766, updated on 10-Dec-2024

Summary

Official Symbol
SUSD6provided by HGNC
Official Full Name
sushi domain containing 6provided by HGNC
Primary source
HGNC:HGNC:19956
See related
Ensembl:ENSG00000100647 MIM:616761; AllianceGenome:HGNC:19956
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRAGO; KIAA0247
Summary
Involved in DNA damage response. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 26.4), appendix (RPKM 20.7) and 25 other tissues See more
Orthologs
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Genomic context

See SUSD6 in Genome Data Viewer
Location:
14q24.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (69611596..69715144)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (63819270..63922809)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70078313..70181861)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene RPL24 pseudogene 3 Neighboring gene coiled-coil domain containing 177 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:70061623-70061793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8638 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8639 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70088656-70089156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8640 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:70104475-70104987 Neighboring gene Sharpr-MPRA regulatory region 10837 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70124416-70125196 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8645 Neighboring gene Sharpr-MPRA regulatory region 2331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8646 Neighboring gene Sharpr-MPRA regulatory region 930 Neighboring gene Sharpr-MPRA regulatory region 8327 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:70207027-70208226 Neighboring gene uncharacterized LOC100289511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70233975-70234739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8649 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:70237232-70238431 Neighboring gene serine and arginine rich splicing factor 5 Neighboring gene solute carrier family 10 member 1 Neighboring gene Sharpr-MPRA regulatory region 10266

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Clone Names

  • KIAA0247

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in DNA damage response  
involved_in DNA damage response PubMed 
Component Evidence Code Pubs
located_in membrane  

General protein information

Preferred Names
sushi domain-containing protein 6
Names
drug-activated gene overexpressed protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014734.4NP_055549.1  sushi domain-containing protein 6 precursor

    See identical proteins and their annotated locations for NP_055549.1

    Status: VALIDATED

    Source sequence(s)
    AL355837, D87434, DC346928
    Consensus CDS
    CCDS9796.1
    UniProtKB/Swiss-Prot
    Q92537
    Related
    ENSP00000344424.4, ENST00000342745.5
    Conserved Domains (1) summary
    cd00033
    Location:42103
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    69611596..69715144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    63819270..63922809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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