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    API5 apoptosis inhibitor 5 [ Homo sapiens (human) ]

    Gene ID: 8539, updated on 10-Dec-2024

    Summary

    Official Symbol
    API5provided by HGNC
    Official Full Name
    apoptosis inhibitor 5provided by HGNC
    Primary source
    HGNC:HGNC:594
    See related
    Ensembl:ENSG00000166181 MIM:609774; AllianceGenome:HGNC:594
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AAC11; AAC-11
    Summary
    This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.0), lymph node (RPKM 15.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See API5 in Genome Data Viewer
    Location:
    11p12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (43311996..43344529)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (43467432..43499960)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (43333546..43366079)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43121800-43122300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4639 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43233497-43234097 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43234098-43234697 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43290423-43290924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:43290925-43291424 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:43333299-43334074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:43372671-43373334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4640 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3267 Neighboring gene tetratricopeptide repeat domain 17 Neighboring gene RN7SK pseudogene 287 Neighboring gene peptidylprolyl isomerase A pseudogene 41

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ11587

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding PubMed 
    enables RNA binding  
    enables fibroblast growth factor binding PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in membrane PubMed 
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus PubMed 
    part_of spliceosomal complex PubMed 

    General protein information

    Preferred Names
    apoptosis inhibitor 5
    Names
    FIF
    antiapoptosis clone 11 protein
    cell migration-inducing gene 8 protein
    fibroblast growth factor 2-interacting factor 2
    migration-inducing protein MIG8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029841.2 RefSeqGene

      Range
      5002..37535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001142930.2NP_001136402.1  apoptosis inhibitor 5 isoform a

      See identical proteins and their annotated locations for NP_001136402.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC087276
      Consensus CDS
      CCDS44572.1
      UniProtKB/Swiss-Prot
      B4DGR0, B4DRJ2, B4E283, D3DR21, G3V1C3, O15441, Q9BZZ5, Q9Y4J7
      Related
      ENSP00000431391.1, ENST00000531273.6
      Conserved Domains (2) summary
      sd00044
      Location:6391
      HEAT; HEAT repeat [structural motif]
      pfam05918
      Location:4496
      API5; Apoptosis inhibitory protein 5 (API5)
    2. NM_001142931.2NP_001136403.1  apoptosis inhibitor 5 isoform c

      See identical proteins and their annotated locations for NP_001136403.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform c) lacks an internal segment in the N-terminal region and has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC087276
      Consensus CDS
      CCDS44573.1
      UniProtKB/Swiss-Prot
      Q9BZZ5
      Related
      ENSP00000402540.2, ENST00000420461.6
      Conserved Domains (1) summary
      pfam05918
      Location:4441
      API5; Apoptosis inhibitory protein 5 (API5)
    3. NM_001243747.2NP_001230676.1  apoptosis inhibitor 5 isoform d

      See identical proteins and their annotated locations for NP_001230676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform d) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC087276
      UniProtKB/TrEMBL
      B4DDR3, E7ETZ6
      Conserved Domains (2) summary
      sd00044
      Location:6391
      HEAT; HEAT repeat [structural motif]
      pfam05918
      Location:4322
      API5; Apoptosis inhibitory protein 5 (API5)
    4. NM_006595.4NP_006586.1  apoptosis inhibitor 5 isoform b

      See identical proteins and their annotated locations for NP_006586.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a small segment in the 3' coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC087276
      Consensus CDS
      CCDS31465.1
      UniProtKB/Swiss-Prot
      Q9BZZ5
      Related
      ENSP00000368129.3, ENST00000378852.7
      Conserved Domains (2) summary
      sd00044
      Location:6391
      HEAT; HEAT repeat [structural motif]
      pfam05918
      Location:4496
      API5; Apoptosis inhibitory protein 5 (API5)

    RNA

    1. NR_024625.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) includes an additional exon in the 5' region, which includes an in-frame stop codon, compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate (NMD), so does not make a functional protein.
      Source sequence(s)
      AC087276

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      43311996..43344529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006718359.5XP_006718422.1  apoptosis inhibitor 5 isoform X1

      See identical proteins and their annotated locations for XP_006718422.1

      Conserved Domains (2) summary
      sd00044
      Location:6391
      HEAT; HEAT repeat [structural motif]
      pfam05918
      Location:4496
      API5; Apoptosis inhibitory protein 5 (API5)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      43467432..43499960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370324.1XP_054226299.1  apoptosis inhibitor 5 isoform X1

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