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    GTF3C1 general transcription factor IIIC subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2975, updated on 10-Dec-2024

    Summary

    Official Symbol
    GTF3C1provided by HGNC
    Official Full Name
    general transcription factor IIIC subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4664
    See related
    Ensembl:ENSG00000077235 MIM:603246; AllianceGenome:HGNC:4664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TFIIIC; TFIIIC220; TFIIICalpha
    Summary
    Enables RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and transcription initiation at RNA polymerase III promoter. Located in nucleolus and nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 19.5), prostate (RPKM 18.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GTF3C1 in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (27460613..27549913, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (27739371..27828673, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (27471934..27561234, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene interleukin 21 receptor Neighboring gene uncharacterized LOC124903668 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27460829-27461706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10632 Neighboring gene IL21R antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27482643-27483144 Neighboring gene MPRA-validated peak2546 silencer Neighboring gene Sharpr-MPRA regulatory regions 5680 and 15498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10633 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10634 Neighboring gene katanin interacting protein Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr16:27644974-27645660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27648141-27648641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27652441-27653082 Neighboring gene uncharacterized LOC107984874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:27711973-27712473 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27713579-27714080 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr16:27714081-27714580 Neighboring gene uncharacterized LOC100128079

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp686A111

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in membrane PubMed 
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    part_of ribonucleoprotein complex  
    part_of transcription factor TFIIIC complex  
    part_of transcription factor TFIIIC complex PubMed 

    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 1
    Names
    TF3C-alpha
    TFIIIC 220 kDa subunit
    TFIIIC box B-binding subunit
    general transcription factor IIIC, polypeptide 1 (alpha subunit)
    general transcription factor IIIC, polypeptide 1, alpha 220kDa
    transcription factor IIIC 220 kDa subunit
    transcription factor IIIC subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286242.2NP_001273171.1  general transcription factor 3C polypeptide 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC002303, AC025275, BC044857, BC137229
      Consensus CDS
      CCDS66988.1
      UniProtKB/TrEMBL
      Q6AHZ7
      Related
      ENSP00000455417.1, ENST00000561623.5
      Conserved Domains (1) summary
      pfam04182
      Location:174250
      B-block_TFIIIC; B-block binding subunit of TFIIIC
    2. NM_001520.4NP_001511.2  general transcription factor 3C polypeptide 1 isoform 1

      See identical proteins and their annotated locations for NP_001511.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC044857, BC137229, BP283960, CA414192
      Consensus CDS
      CCDS32414.1
      UniProtKB/Swiss-Prot
      B2RP21, Q12789, Q12838, Q6DKN9, Q9Y4W9
      UniProtKB/TrEMBL
      Q6AHZ7
      Related
      ENSP00000348510.4, ENST00000356183.9
      Conserved Domains (2) summary
      pfam04182
      Location:174250
      B-block_TFIIIC; B-block binding subunit of TFIIIC
      cl22974
      Location:18811975
      HpaP; Type III secretion protein (HpaP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      27460613..27549913 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434036.1XP_047289992.1  general transcription factor 3C polypeptide 1 isoform X2

      UniProtKB/TrEMBL
      Q6AHZ7
    2. XM_017023188.3XP_016878677.1  general transcription factor 3C polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      Q6AHZ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      27739371..27828673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380183.1XP_054236158.1  general transcription factor 3C polypeptide 1 isoform X2

      UniProtKB/TrEMBL
      Q6AHZ7
    2. XM_054380182.1XP_054236157.1  general transcription factor 3C polypeptide 1 isoform X1

      UniProtKB/TrEMBL
      Q6AHZ7
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