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    fzd8a frizzled class receptor 8a [ Danio rerio (zebrafish) ]

    Gene ID: 58073, updated on 9-Dec-2024

    Summary

    Official Symbol
    fzd8aprovided by ZNC
    Official Full Name
    frizzled class receptor 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000328-3
    See related
    Ensembl:ENSDARG00000045444 AllianceGenome:ZFIN:ZDB-GENE-000328-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fz5; fzc; fz8a; zg05; wu:fd02c05
    Summary
    Predicted to enable Wnt receptor activity and Wnt-protein binding activity. Acts upstream of or within canonical Wnt signaling pathway; eye field cell fate commitment involved in camera-type eye formation; and neurogenesis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; neural keel; and pectoral fin. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See fzd8a in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (4447634..4450238, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (4415847..4418451, complement)

    Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene gap junction protein delta 4 Neighboring gene uncharacterized LOC137489204 Neighboring gene carboxypeptidase B1 (tissue)

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Wnt receptor activity  
    enables Wnt-protein binding  
    enables transmembrane signaling receptor activity  
    Component Evidence Code Pubs
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    frizzled-8a
    Names
    frizzled homolog 8a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130918.2NP_570993.2  frizzled-8a precursor

      See identical proteins and their annotated locations for NP_570993.2

      Status: PROVISIONAL

      Source sequence(s)
      BC056273
      UniProtKB/TrEMBL
      Q6P4V8, Q9YI00
      Related
      ENSDARP00000066834.4, ENSDART00000066835.6
      Conserved Domains (2) summary
      cd07461
      Location:26150
      CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
      cd15250
      Location:228537
      7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007135.7 Reference GRCz11 Primary Assembly

      Range
      4447634..4450238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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