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Avpr1a arginine vasopressin receptor 1A [ Mus musculus (house mouse) ]

Gene ID: 54140, updated on 9-Dec-2024

Summary

Official Symbol
Avpr1aprovided by MGI
Official Full Name
arginine vasopressin receptor 1Aprovided by MGI
Primary source
MGI:MGI:1859216
See related
Ensembl:ENSMUSG00000020123 AllianceGenome:MGI:1859216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
V1a; AVPR; V1aR; Avpr1
Summary
This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver adult (RPKM 15.9), bladder adult (RPKM 11.1) and 13 other tissues See more
Orthologs
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Genomic context

See Avpr1a in Genome Data Viewer
Location:
10 D2; 10 70.36 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (122284404..122289358)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (122448499..122453453)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28119 Neighboring gene predicted gene, 40790 Neighboring gene STARR-seq mESC enhancer starr_28120 Neighboring gene predicted gene, 36041 Neighboring gene STARR-seq mESC enhancer starr_28121 Neighboring gene STARR-seq mESC enhancer starr_28122 Neighboring gene STARR-seq mESC enhancer starr_28123 Neighboring gene predicted gene, 40791 Neighboring gene non-coding RNA suppressor of Stat1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 
  • Targeted (11)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables V1A vasopressin receptor binding  
enables V1A vasopressin receptor binding  
enables peptide hormone binding  
enables peptide hormone binding  
enables vasopressin receptor activity  
enables vasopressin receptor activity  
enables vasopressin receptor activity  
Items 1 - 25 of 46
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in G protein-coupled receptor signaling pathway  
involved_in calcium-mediated signaling  
involved_in calcium-mediated signaling  
involved_in cellular response to hormone stimulus  
involved_in cellular response to water deprivation  
involved_in grooming behavior  
involved_in grooming behavior  
involved_in maternal aggressive behavior  
involved_in maternal aggressive behavior  
involved_in maternal behavior  
involved_in maternal behavior  
involved_in myotube differentiation  
involved_in negative regulation of female receptivity  
involved_in negative regulation of female receptivity  
involved_in negative regulation of transmission of nerve impulse  
involved_in negative regulation of transmission of nerve impulse  
involved_in positive regulation of blood pressure  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cellular pH reduction  
involved_in positive regulation of cellular pH reduction  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of cytosolic calcium ion concentration  
involved_in positive regulation of glutamate secretion  
involved_in positive regulation of glutamate secretion  
involved_in positive regulation of heart rate  
involved_in positive regulation of heart rate  
involved_in positive regulation of prostaglandin biosynthetic process  
involved_in positive regulation of prostaglandin biosynthetic process  
involved_in positive regulation of systemic arterial blood pressure  
involved_in positive regulation of systemic arterial blood pressure  
involved_in positive regulation of vasoconstriction  
involved_in positive regulation of vasoconstriction  
involved_in positive regulation of vasoconstriction  
involved_in regulation of blood pressure PubMed 
involved_in regulation of systemic arterial blood pressure by vasopressin  
acts_upstream_of_or_within regulation of systemic arterial blood pressure by vasopressin PubMed 
involved_in response to corticosterone  
involved_in social behavior  
involved_in social behavior  
involved_in sperm ejaculation  
involved_in sperm ejaculation  
involved_in telencephalon development  
Items 1 - 25 of 46
Component Evidence Code Pubs
located_in endocytic vesicle  
located_in endocytic vesicle  
located_in endosome  
located_in endosome  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
vasopressin V1a receptor
Names
AVPR V1a
V1a arginine vasopressin receptor
antidiuretic hormone receptor 1a
vascular/hepatic-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016847.2NP_058543.2  vasopressin V1a receptor

    See identical proteins and their annotated locations for NP_058543.2

    Status: REVIEWED

    Source sequence(s)
    D49730
    Consensus CDS
    CCDS24215.1
    UniProtKB/Swiss-Prot
    Q62463, Q62464, Q9QYH2
    UniProtKB/TrEMBL
    Q3U1H9, Q3UEE1
    Related
    ENSMUSP00000020323.6, ENSMUST00000020323.7
    Conserved Domains (3) summary
    pfam00001
    Location:68353
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam08983
    Location:377423
    DUF1856; Domain of unknown function (DUF1856)
    cl21561
    Location:62259
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    122284404..122289358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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