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lfe-2 Inositol-trisphosphate 3-kinase homolog [ Caenorhabditis elegans ]

Gene ID: 172128, updated on 9-Dec-2024

Summary

Official Symbol
lfe-2
Official Full Name
Inositol-trisphosphate 3-kinase homolog
Primary source
WormBase:WBGene00002979
Locus tag
CELE_C46H11.4
See related
AllianceGenome:WB:WBGene00002979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable inositol tetrakisphosphate kinase activity and inositol-1,4,5-trisphosphate 3-kinase activity. Predicted to be involved in inositol phosphate biosynthetic process. Predicted to be active in cytoplasm and nucleus. Is expressed in intestine; pharynx; and spermatheca. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A); ITPKB (inositol-trisphosphate 3-kinase B); and ITPKC (inositol-trisphosphate 3-kinase C). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See lfe-2 in Genome Data Viewer
Location:
chromosome: I
Exon count:
13
Sequence:
Chromosome: I; NC_003279.8 (5027155..5041160)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene PDZ domain-containing protein Neighboring gene putative actin-related protein 2/3 complex subunit 5 Neighboring gene ShKT domain-containing protein

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding  
enables inositol hexakisphosphate kinase activity  
enables inositol-1,4,5-trisphosphate 3-kinase activity  
enables kinase activity  
Component Evidence Code Pubs
is_active_in cytoplasm  
is_active_in nucleus  

General protein information

Preferred Names
Inositol-trisphosphate 3-kinase homolog
NP_001021047.1
  • Partially confirmed by transcript evidence
NP_001021048.1
  • Confirmed by transcript evidence
NP_001021049.1
  • Confirmed by transcript evidence
NP_001249778.1
  • Partially confirmed by transcript evidence
NP_001359911.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    5027155..5041160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025878.8NP_001021049.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q62
    Conserved Domains (1) summary
    pfam03770
    Location:223433
    IPK; Inositol polyphosphate kinase
  2. NM_001262849.3NP_001249778.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001249778.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q62
    Conserved Domains (1) summary
    pfam03770
    Location:236446
    IPK; Inositol polyphosphate kinase
  3. NM_001372686.1NP_001359911.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam03770
    Location:187397
    IPK; Inositol polyphosphate kinase
  4. NM_001025877.6NP_001021048.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021048.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95Q62
    Conserved Domains (1) summary
    pfam03770
    Location:156366
    IPK; Inositol polyphosphate kinase
  5. NM_001025876.5NP_001021047.1  Inositol-trisphosphate 3-kinase homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021047.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KZ42, H2KZ43, H2KZ45, H2KZ46, H2KZ47, O45049, O45050, O45051, Q95Q62
    Conserved Domains (1) summary
    pfam03770
    Location:256466
    IPK; Inositol polyphosphate kinase
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