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tek TEK tyrosine kinase, endothelial [ Danio rerio (zebrafish) ]

Gene ID: 30747, updated on 9-Dec-2024

Summary

Official Symbol
tekprovided by ZNC
Official Full Name
TEK tyrosine kinase, endothelialprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-56
See related
Ensembl:ENSDARG00000028663 AllianceGenome:ZFIN:ZDB-GENE-990415-56
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tie2; tie-2
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within angiogenesis and heart development. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and focal adhesion. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in endothelial cell; vasculature; and vertical myoseptum. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See tek in Genome Data Viewer
Location:
chromosome: 5
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (480080..496790)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (473662..497870)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495540 Neighboring gene intraflagellar transport 74 Neighboring gene uncharacterized LOC101883870 Neighboring gene uncharacterized LOC110439795

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
enables kinase activity  
enables nucleotide binding  
enables protein kinase activity  
enables protein tyrosine kinase activity  
enables transferase activity  
enables transmembrane receptor protein tyrosine kinase activity  
enables transmembrane receptor protein tyrosine kinase activity  
Process Evidence Code Pubs
involved_in angiogenesis  
acts_upstream_of_or_within angiogenesis PubMed 
acts_upstream_of_or_within angiogenesis PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway  
acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway  
involved_in endothelial cell proliferation  
acts_upstream_of_or_within heart development PubMed 
involved_in multicellular organism development  
acts_upstream_of_or_within phosphorylation  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of endothelial cell migration  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within protein phosphorylation  
Component Evidence Code Pubs
located_in anchoring junction  
located_in cytoplasm  
located_in cytoskeleton  
located_in focal adhesion  
located_in membrane  
is_active_in plasma membrane  
located_in plasma membrane  
part_of receptor complex  

General protein information

Preferred Names
angiopoietin-1 receptor
Names
endothelium-specific receptor tyrosine kinase 2
tyrosine kinase with Ig and EGF homology domains-2
tyrosine-protein kinase receptor Tie-2
NP_571536.1
XP_009299388.1
XP_021331678.1
XP_021331680.1
XP_068077196.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131461.1NP_571536.1  angiopoietin-1 receptor precursor

    See identical proteins and their annotated locations for NP_571536.1

    Status: PROVISIONAL

    Source sequence(s)
    AF053632
    UniProtKB/Swiss-Prot
    O73791
    Related
    ENSDARP00000055680.5, ENSDART00000055681.7
    Conserved Domains (7) summary
    cd05088
    Location:8081110
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:632716
    FN3; Fibronectin type 3 domain
    smart00221
    Location:8161084
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:354439
    IG_like; Immunoglobulin like
    pfam00041
    Location:541621
    fn3; Fibronectin type III domain
    pfam07974
    Location:224255
    EGF_2; EGF-like domain
    pfam10430
    Location:25121
    Ig_Tie2_1; Tie-2 Ig-like domain 1

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    480080..496790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301113.4XP_009299388.1  angiopoietin-1 receptor isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARU2
    Conserved Domains (7) summary
    cd05088
    Location:8091111
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:633717
    FN3; Fibronectin type 3 domain
    smart00221
    Location:8171085
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:354439
    IG_like; Immunoglobulin like
    pfam00041
    Location:541621
    fn3; Fibronectin type III domain
    pfam07974
    Location:224255
    EGF_2; EGF-like domain
    pfam10430
    Location:25121
    Ig_Tie2_1; Tie-2 Ig-like domain 1
  2. XM_068221095.1XP_068077196.1  angiopoietin-1 receptor isoform X2

  3. XM_021476003.2XP_021331678.1  angiopoietin-1 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8M9PX37
    Conserved Domains (5) summary
    cd05088
    Location:689991
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:513597
    FN3; Fibronectin type 3 domain
    smart00410
    Location:234319
    IG_like; Immunoglobulin like
    pfam07974
    Location:104135
    EGF_2; EGF-like domain
    pfam00041
    Location:421501
    fn3; Fibronectin type III domain
  4. XM_021476005.2XP_021331680.1  angiopoietin-1 receptor isoform X3

    UniProtKB/TrEMBL
    A0A8M9PX37
    Conserved Domains (5) summary
    cd05088
    Location:689991
    PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
    smart00060
    Location:513597
    FN3; Fibronectin type 3 domain
    smart00410
    Location:234319
    IG_like; Immunoglobulin like
    pfam07974
    Location:104135
    EGF_2; EGF-like domain
    pfam00041
    Location:421501
    fn3; Fibronectin type III domain

RNA

  1. XR_002458735.2 RNA Sequence

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