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ZNF506 zinc finger protein 506 [ Homo sapiens (human) ]

Gene ID: 440515, updated on 10-Dec-2024

Summary

Official Symbol
ZNF506provided by HGNC
Official Full Name
zinc finger protein 506provided by HGNC
Primary source
HGNC:HGNC:23780
See related
Ensembl:ENSG00000081665 AllianceGenome:HGNC:23780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in thyroid (RPKM 8.8), lymph node (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF506 in Genome Data Viewer
Location:
19p13.11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (19792711..19821750, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (19930412..19959452, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (19903520..19932559, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060187 Neighboring gene sorting nexin 18 pseudogene Neighboring gene long intergenic non-protein coding RNA 663 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19887366-19888257 Neighboring gene zinc finger protein 56, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14372 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:19932265-19932779 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 5 Neighboring gene BCL2 interacting protein 3 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Interactions

General gene information

Clone Names

  • MGC27136, DKFZp761G1812

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleolus  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099269.3NP_001092739.1  zinc finger protein 506 isoform 1

    See identical proteins and their annotated locations for NP_001092739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC011477, AI559570, AK095575, DA122515
    Consensus CDS
    CCDS42531.1
    UniProtKB/Swiss-Prot
    B3KTH6, Q5JVG8
    Related
    ENSP00000440625.1, ENST00000540806.7
    Conserved Domains (5) summary
    smart00349
    Location:462
    KRAB; krueppel associated box
    COG5048
    Location:255417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:643
    KRAB; KRAB box
    pfam13465
    Location:215240
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001145404.2NP_001138876.1  zinc finger protein 506 isoform 2

    See identical proteins and their annotated locations for NP_001138876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC011477, AI559570, AK095575, AK122848
    Consensus CDS
    CCDS46027.1
    UniProtKB/Swiss-Prot
    Q5JVG8
    Related
    ENSP00000408892.1, ENST00000450683.6
    Conserved Domains (5) summary
    smart00349
    Location:443
    KRAB; krueppel associated box
    COG5048
    Location:223385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:643
    KRAB; KRAB box
    pfam13465
    Location:183208
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    19792711..19821750 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    19930412..19959452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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