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Nat8l N-acetyltransferase 8-like [ Mus musculus (house mouse) ]

Gene ID: 269642, updated on 9-Dec-2024

Summary

Official Symbol
Nat8lprovided by MGI
Official Full Name
N-acetyltransferase 8-likeprovided by MGI
Primary source
MGI:MGI:2447776
See related
Ensembl:ENSMUSG00000048142 AllianceGenome:MGI:2447776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Shati; 1110038O08Rik
Summary
Enables aspartate N-acetyltransferase activity. Involved in acetate metabolic process; aspartate metabolic process; and positive regulation of dopamine uptake involved in synaptic transmission. Located in endoplasmic reticulum membrane. Is active in mitochondrial matrix. Is expressed in several structures, including central nervous system; hemolymphoid system gland; intestine; lung; and retina. Orthologous to human NAT8L (N-acetyltransferase 8 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in cerebellum adult (RPKM 48.7), cortex adult (RPKM 39.5) and 11 other tissues See more
Orthologs
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Genomic context

See Nat8l in Genome Data Viewer
Location:
5 B2; 5 17.83 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34153328..34163260)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33995984..34005916)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30802 Neighboring gene NELL2 interacting cell ontogeny regulator 1 Neighboring gene DNA polymerase N Neighboring gene STARR-seq mESC enhancer starr_12835 Neighboring gene RIKEN cDNA 4930557J02 gene Neighboring gene HAUS augmin-like complex, subunit 3 Neighboring gene predicted gene, 25918

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytoplasm  
located_in endoplasmic reticulum membrane PubMed 
located_in intracellular membrane-bounded organelle  
is_active_in mitochondrial matrix PubMed 
is_active_in mitochondrial membrane  
located_in mitochondrial membrane  
located_in mitochondrial membrane  
located_in mitochondrion  
located_in mitochondrion  

General protein information

Preferred Names
N-acetylaspartate synthetase
Names
N-acetyltransferase 8-like protein
NAA synthase
NAA synthetase
aspartate N-acetyltransferase
protein Shati
NP_001001985.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001985.3NP_001001985.3  N-acetylaspartate synthetase

    See identical proteins and their annotated locations for NP_001001985.3

    Status: VALIDATED

    Source sequence(s)
    AC163329, AK147594
    Consensus CDS
    CCDS19210.1
    UniProtKB/Swiss-Prot
    Q3UGX3, Q3UH43, Q6DID6, Q8K065
    UniProtKB/TrEMBL
    A0A0R4J0R4
    Related
    ENSMUSP00000059313.9, ENSMUST00000056355.9
    Conserved Domains (2) summary
    COG0456
    Location:146270
    RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    pfam00583
    Location:187262
    Acetyltransf_1; Acetyltransferase (GNAT) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34153328..34163260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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