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    Nme7 NME/NM23 family member 7 [ Mus musculus (house mouse) ]

    Gene ID: 171567, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nme7provided by MGI
    Official Full Name
    NME/NM23 family member 7provided by MGI
    Primary source
    MGI:MGI:2449121
    See related
    Ensembl:ENSMUSG00000026575 AllianceGenome:MGI:2449121
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nm23-M7; Nm23-r7; nm23-H7; D530024H21Rik
    Summary
    Predicted to enable 3'-5' exonuclease activity and protein kinase activity. Involved in flagellated sperm motility. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; epithelial cilium movement involved in extracellular fluid movement; and intraciliary transport. Located in axonemal microtubule; centrosome; and ciliary basal body. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study hydrocephalus. Orthologous to human NME7 (NME/NM23 family member 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 15.5), cortex adult (RPKM 15.3) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nme7 in Genome Data Viewer
    Location:
    1 H2.2; 1 71.63 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164135091..164264870)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164307524..164437300)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02867 Neighboring gene coiled-coil domain containing 181 Neighboring gene STARR-positive B cell enhancer ABC_E797 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E5840 Neighboring gene STARR-seq mESC enhancer starr_02870 Neighboring gene predicted gene, 39690 Neighboring gene ATPase, Na+/K+ transporting, beta 1 polypeptide Neighboring gene predicted gene, 32391 Neighboring gene predicted gene, 39691

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity  
    enables 3'-5' exonuclease activity  
    enables ATP binding  
    enables metal ion binding  
    enables nucleoside diphosphate kinase activity  
    enables protein kinase activity  
    enables protein kinase activity  
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath PubMed 
    is_active_in axonemal microtubule  
    located_in axonemal microtubule PubMed 
    located_in axonemal microtubule  
    located_in axonemal microtubule  
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in centrosome  
    located_in ciliary basal body PubMed 
    located_in cytoplasm  
    located_in extracellular region  
    part_of gamma-tubulin ring complex  
    part_of gamma-tubulin ring complex  
    located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    is_active_in sperm flagellum PubMed 
    located_in spindle  

    General protein information

    Preferred Names
    nucleoside diphosphate kinase homolog 7; nucleoside diphosphate kinase 7
    Names
    3'-5' exonuclease NME7
    NDK 7
    NDP kinase 7
    NDP kinase homolog 7
    non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
    nucleoside-diphosphate kinase
    protein kinase NME7
    NP_001280242.1
    NP_612187.2
    NP_835172.1
    XP_006496755.1
    XP_006496756.1
    XP_030107778.1
    XP_030107781.1
    XP_036018403.1
    XP_036018404.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293313.1NP_001280242.1  nucleoside diphosphate kinase homolog 7 isoform 1

      See identical proteins and their annotated locations for NP_001280242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (1).
      Source sequence(s)
      AK133221, BU609451
      Consensus CDS
      CCDS15436.2
      UniProtKB/Swiss-Prot
      Q3UMG6, Q9QXL8
      UniProtKB/TrEMBL
      Q80UP4
      Related
      ENSMUSP00000141431.2, ENSMUST00000191947.6
      Conserved Domains (4) summary
      smart00676
      Location:22110
      DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
      smart00562
      Location:111244
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04412
      Location:257390
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:111241
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
    2. NM_138314.4NP_612187.2  nucleoside diphosphate kinase homolog 7 isoform 1

      See identical proteins and their annotated locations for NP_612187.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AK133221, BU609451
      Consensus CDS
      CCDS15436.2
      UniProtKB/Swiss-Prot
      Q3UMG6, Q9QXL8
      UniProtKB/TrEMBL
      Q80UP4
      Related
      ENSMUSP00000141963.2, ENSMUST00000193683.6
      Conserved Domains (4) summary
      smart00676
      Location:22110
      DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
      smart00562
      Location:111244
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04412
      Location:257390
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:111241
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
    3. NM_178071.6NP_835172.1  nucleoside diphosphate kinase homolog 7 isoform 2

      See identical proteins and their annotated locations for NP_835172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to isoform 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK085222, AK133221
      Consensus CDS
      CCDS78731.1
      UniProtKB/TrEMBL
      Q8BUH2
      Related
      ENSMUSP00000083192.6, ENSMUST00000086028.6
      Conserved Domains (4) summary
      smart00676
      Location:22110
      DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
      smart00562
      Location:111244
      NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
      cd04415
      Location:111241
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl00335
      Location:257272
      NDPk; Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      164135091..164264870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496692.4XP_006496755.1  nucleoside diphosphate kinase 7 isoform X3

      See identical proteins and their annotated locations for XP_006496755.1

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      cd04412
      Location:202335
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:56186
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl26962
      Location:355
      DUF1126; DUF1126 PH-like domain
    2. XM_036162511.1XP_036018404.1  nucleoside diphosphate kinase 7 isoform X2

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      cd04412
      Location:221354
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:75205
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl26962
      Location:2274
      DUF1126; DUF1126 PH-like domain
    3. XM_006496693.5XP_006496756.1  nucleoside diphosphate kinase 7 isoform X3

      See identical proteins and their annotated locations for XP_006496756.1

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      cd04412
      Location:202335
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:56186
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl26962
      Location:355
      DUF1126; DUF1126 PH-like domain
    4. XM_030251918.2XP_030107778.1  nucleoside diphosphate kinase 7 isoform X3

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      cd04412
      Location:202335
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:56186
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl26962
      Location:355
      DUF1126; DUF1126 PH-like domain
    5. XM_036162510.1XP_036018403.1  nucleoside diphosphate kinase 7 isoform X1

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      smart00676
      Location:35123
      DM10; Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases
      cd04412
      Location:270403
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:124254
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
    6. XM_030251921.2XP_030107781.1  nucleoside diphosphate kinase 7 isoform X3

      UniProtKB/TrEMBL
      Q05BM9
      Conserved Domains (3) summary
      cd04412
      Location:202335
      NDPk7B; Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cd04415
      Location:56186
      NDPk7A; Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also ...
      cl26962
      Location:355
      DUF1126; DUF1126 PH-like domain
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