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SH3BGRL3 SH3 domain binding glutamate rich protein like 3 [ Homo sapiens (human) ]

Gene ID: 83442, updated on 10-Dec-2024

Summary

Official Symbol
SH3BGRL3provided by HGNC
Official Full Name
SH3 domain binding glutamate rich protein like 3provided by HGNC
Primary source
HGNC:HGNC:15568
See related
Ensembl:ENSG00000142669 MIM:615679; AllianceGenome:HGNC:15568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP-B1; SH3BP-1; HEL-S-297
Summary
Involved in cytoskeleton organization. Located in cytosol; nuclear body; and ruffle membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in appendix (RPKM 140.1), colon (RPKM 114.4) and 25 other tissues See more
Orthologs
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Genomic context

See SH3BGRL3 in Genome Data Viewer
Location:
1p36.11
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26280086..26281522)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26117570..26119006)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (26606577..26608013)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene centrosomal protein 85 Neighboring gene uncharacterized LOC124904684 Neighboring gene MPRA-validated peak133 silencer Neighboring gene mitochondrial ribosomal protein S6 pseudogene 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:26602348-26603547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606098-26606985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26606986-26607872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26610368-26610958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 488 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26616244-26617056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:26617057-26617870 Neighboring gene UBX domain protein 11 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:26629035-26630234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 493 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:26644239-26644431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26645229-26646214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:26648235-26648736 Neighboring gene CD52 molecule Neighboring gene crystallin beta-gamma domain containing 2 Neighboring gene ribosomal protein L34 pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytosol PubMed 
located_in extracellular exosome PubMed 
located_in nuclear body  
located_in ruffle membrane PubMed 

General protein information

Preferred Names
SH3 domain-binding glutamic acid-rich-like protein 3
Names
SH3 domain binding glutamic acid-rich protein like 3
SH3 domain-binding protein 1
SH3BGRL3-like protein
TNF inhibitory protein
TNF inhibitory protein B1
epididymis secretory protein Li 297
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031286.4NP_112576.1  SH3 domain-binding glutamic acid-rich-like protein 3

    See identical proteins and their annotated locations for NP_112576.1

    Status: VALIDATED

    Source sequence(s)
    BC030135
    Consensus CDS
    CCDS278.1
    UniProtKB/Swiss-Prot
    Q5T122, Q9H299
    Related
    ENSP00000270792.5, ENST00000270792.10
    Conserved Domains (1) summary
    pfam04908
    Location:293
    SH3BGR; SH3-binding, glutamic acid-rich protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26280086..26281522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26117570..26119006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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