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Ndfip1 Nedd4 family interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 65113, updated on 9-Dec-2024

Summary

Official Symbol
Ndfip1provided by MGI
Official Full Name
Nedd4 family interacting protein 1provided by MGI
Primary source
MGI:MGI:1929601
See related
Ensembl:ENSMUSG00000024425 AllianceGenome:MGI:1929601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N4wbp5; 0610010M22Rik
Summary
Enables WW domain binding activity. Acts upstream of or within several processes, including negative regulation of interleukin-4 production; negative regulation of type 2 immune response; and regulation of lymphocyte activation. Located in Golgi apparatus and cell cortex. Is expressed in several structures, including alimentary system; nervous system; retina; and rib. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 223.7), CNS E18 (RPKM 122.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ndfip1 in Genome Data Viewer
Location:
18 B3; 18 20.32 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (38551960..38598250)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (38418907..38465197)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44356 Neighboring gene STARR-positive B cell enhancer ABC_E7581 Neighboring gene STARR-seq mESC enhancer starr_44358 Neighboring gene predicted gene, 41703 Neighboring gene glutamate-ammonia ligase (glutamine synthetase) pseudogene Neighboring gene VISTA enhancer mm1457 Neighboring gene STARR-seq mESC enhancer starr_44361 Neighboring gene STARR-positive B cell enhancer ABC_E11658 Neighboring gene STARR-positive B cell enhancer ABC_E8713 Neighboring gene STARR-positive B cell enhancer ABC_E8714 Neighboring gene predicted gene, 41704 Neighboring gene STARR-seq mESC enhancer starr_44367 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables WW domain binding PubMed 
enables protein binding PubMed 
Items 1 - 25 of 26
Process Evidence Code Pubs
acts_upstream_of CD4-positive, alpha-beta T cell proliferation PubMed 
acts_upstream_of interleukin-4 production PubMed 
involved_in intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in metal ion transport  
acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation PubMed 
involved_in negative regulation of gene expression  
acts_upstream_of_or_within negative regulation of inflammatory response PubMed 
acts_upstream_of_or_within negative regulation of interleukin-4 production PubMed 
acts_upstream_of_or_within negative regulation of isotype switching to IgE isotypes PubMed 
involved_in negative regulation of protein transport  
involved_in negative regulation of protein transport  
involved_in negative regulation of transporter activity  
acts_upstream_of_or_within negative regulation of type 2 immune response PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process PubMed 
involved_in positive regulation of protein ubiquitination  
involved_in positive regulation of protein ubiquitination  
involved_in positive regulation of protein ubiquitination  
acts_upstream_of protein catabolic process PubMed 
acts_upstream_of protein catabolic process PubMed 
acts_upstream_of_or_within regulation of isotype switching to IgG isotypes PubMed 
acts_upstream_of_or_within regulation of lymphocyte differentiation PubMed 
acts_upstream_of_or_within regulation of myeloid leukocyte differentiation PubMed 
involved_in ubiquitin-dependent protein catabolic process  
involved_in vacuolar transport  
Items 1 - 25 of 26
Component Evidence Code Pubs
is_active_in Golgi apparatus  
located_in Golgi apparatus PubMed 
located_in Golgi membrane PubMed 
located_in cell cortex PubMed 
located_in dendrite  
is_active_in endoplasmic reticulum  
located_in endosome membrane  
located_in extracellular region  
located_in membrane PubMed 
is_active_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in perinuclear region of cytoplasm  
located_in synapse  

General protein information

Preferred Names
NEDD4 family-interacting protein 1
Names
NEDD4 WW domain-binding protein 5
Nedd4 WW binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355749.1NP_001342678.1  NEDD4 family-interacting protein 1

    Status: VALIDATED

    Source sequence(s)
    AC134576, AK050560
    Consensus CDS
    CCDS37789.1
    UniProtKB/Swiss-Prot
    Q8R0W6, Q9EQH8
    UniProtKB/TrEMBL
    A0A494BAA4
    Related
    ENSMUSP00000025293.4, ENSMUST00000025293.5
  2. NM_022996.2NP_075372.1  NEDD4 family-interacting protein 1

    See identical proteins and their annotated locations for NP_075372.1

    Status: VALIDATED

    Source sequence(s)
    AC134576
    Consensus CDS
    CCDS37789.1
    UniProtKB/Swiss-Prot
    Q8R0W6, Q9EQH8
    UniProtKB/TrEMBL
    A0A494BAA4
    Related
    ENSMUSP00000158314.2, ENSMUST00000236085.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    38551960..38598250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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