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Itgae integrin alpha E, epithelial-associated [ Mus musculus (house mouse) ]

Gene ID: 16407, updated on 9-Dec-2024

Summary

Official Symbol
Itgaeprovided by MGI
Official Full Name
integrin alpha E, epithelial-associatedprovided by MGI
Primary source
MGI:MGI:1298377
See related
Ensembl:ENSMUSG00000005947 AllianceGenome:MGI:1298377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD103; aM290; alpha-E1; A530055J10; alpha-M290
Summary
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lymph node; nasal septum; and nucleus pulposus. Orthologous to human ITGAE (integrin subunit alpha E). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in thymus adult (RPKM 6.0), testis adult (RPKM 5.9) and 10 other tissues See more
Orthologs
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Genomic context

See Itgae in Genome Data Viewer
Location:
11 B4; 11 45.22 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72981396..73038272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73090505..73147449)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732414G09 gene Neighboring gene STARR-positive B cell enhancer ABC_E10684 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 1, alpha Neighboring gene STARR-positive B cell enhancer ABC_E5246 Neighboring gene nuclear cap binding subunit 3 Neighboring gene STARR-positive B cell enhancer mm9_chr11:72885264-72885564 Neighboring gene STARR-seq mESC enhancer starr_29927 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:72921846-72921999 Neighboring gene STARR-seq mESC enhancer starr_29929 Neighboring gene histone H3 associated protein kinase Neighboring gene purinergic receptor P2X, ligand-gated ion channel, 5 Neighboring gene STARR-positive B cell enhancer ABC_E1141 Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 3 Neighboring gene ER membrane protein complex subunit 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC183601

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding  
enables metal ion binding  
Process Evidence Code Pubs
involved_in cell adhesion  
involved_in cell adhesion mediated by integrin  
involved_in cell-cell adhesion  
involved_in cell-matrix adhesion  
involved_in integrin-mediated signaling pathway  
involved_in integrin-mediated signaling pathway  
Component Evidence Code Pubs
located_in cell surface  
is_active_in external side of plasma membrane  
located_in external side of plasma membrane PubMed 
part_of integrin complex  
part_of integrin complex  

General protein information

Preferred Names
integrin alpha-E
Names
integrin alpha M290

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361245.2NP_001348174.1  integrin alpha-E isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL670399
    UniProtKB/TrEMBL
    Q3U4V9
    Conserved Domains (3) summary
    smart00191
    Location:565624
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:195370
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:667938
    Integrin_alpha2; Integrin alpha
  2. NM_008399.4NP_032425.2  integrin alpha-E isoform 1 precursor

    See identical proteins and their annotated locations for NP_032425.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL670399
    Consensus CDS
    CCDS24995.1
    UniProtKB/Swiss-Prot
    B1AUD5, Q60677
    UniProtKB/TrEMBL
    A2T0Z1, Q3U4V9
    Related
    ENSMUSP00000006101.4, ENSMUST00000006101.4
    Conserved Domains (3) summary
    smart00191
    Location:566625
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:196371
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:668939
    Integrin_alpha2; Integrin alpha

RNA

  1. NR_189133.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399
  2. NR_189134.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399
  3. NR_189135.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399
  4. NR_189136.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL670399

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72981396..73038272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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