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CYP2F1 cytochrome P450 family 2 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 1572, updated on 10-Dec-2024

Summary

Official Symbol
CYP2F1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily F member 1provided by HGNC
Primary source
HGNC:HGNC:2632
See related
Ensembl:ENSG00000197446 MIM:124070; AllianceGenome:HGNC:2632
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C2F1; CYP2F; CYPIIF1
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CYP2F1 in Genome Data Viewer
Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41114432..41128381)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (43935308..43949263)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41620337..41634286)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 2 subfamily G member 2, pseudogene Neighboring gene cytochrome P450 family 2 subfamily A member 13 Neighboring gene uncharacterized LOC124904790 Neighboring gene cytochrome P450 family 2 subfamily T member 3, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:41664953-41665516 Neighboring gene Sharpr-MPRA regulatory region 1789 Neighboring gene ribosomal protein L36 pseudogene 16

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Clone Names

  • MGC126121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epoxygenase P450 pathway  
involved_in naphthalene catabolic process PubMed 
involved_in response to toxic substance  
involved_in xenobiotic metabolic process  
involved_in xenobiotic metabolic process  
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in endoplasmic reticulum membrane  
is_active_in intracellular membrane-bounded organelle  
located_in intracellular membrane-bounded organelle PubMed 

General protein information

Preferred Names
cytochrome P450 2F1
Names
cytochrome P450, family 2, subfamily F, polypeptide 1
cytochrome P450, subfamily IIF, polypeptide 1
flavoprotein-linked monooxygenase
microsomal monooxygenase
xenobiotic monooxygenase
NP_000765.2
XP_047294236.1
XP_047294237.1
XP_047294238.1
XP_054175991.1
XP_054175992.1
XP_054175993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007930.1 RefSeqGene

    Range
    4985..18934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000774.5NP_000765.2  cytochrome P450 2F1

    See identical proteins and their annotated locations for NP_000765.2

    Status: REVIEWED

    Source sequence(s)
    BC109057, CB853363, DC413790
    Consensus CDS
    CCDS12572.1
    UniProtKB/Swiss-Prot
    A7KAU6, A7KAU7, A7KAU8, A7KAU9, A7KAV0, P24903, Q32MN5, Q8WWJ2
    Related
    ENSP00000333534.2, ENST00000331105.7
    Conserved Domains (1) summary
    pfam00067
    Location:31488
    p450; Cytochrome P450

RNA

  1. NR_135528.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008962, AK316498, CB853363

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41114432..41128381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438280.1XP_047294236.1  cytochrome P450 2F1 isoform X1

  2. XM_047438281.1XP_047294237.1  cytochrome P450 2F1 isoform X2

    UniProtKB/TrEMBL
    B4DNV7
  3. XM_047438282.1XP_047294238.1  cytochrome P450 2F1 isoform X3

    UniProtKB/TrEMBL
    B4DNV7
    Related
    ENSP00000471416.1, ENST00000532164.2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    43935308..43949263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320016.1XP_054175991.1  cytochrome P450 2F1 isoform X1

  2. XM_054320017.1XP_054175992.1  cytochrome P450 2F1 isoform X2

    UniProtKB/TrEMBL
    B4DNV7
  3. XM_054320018.1XP_054175993.1  cytochrome P450 2F1 isoform X3

    UniProtKB/TrEMBL
    B4DNV7
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