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    Plk2 polo like kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 20620, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plk2provided by MGI
    Official Full Name
    polo like kinase 2provided by MGI
    Primary source
    MGI:MGI:1099790
    See related
    Ensembl:ENSMUSG00000021701 AllianceGenome:MGI:1099790
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Snk
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process in bone marrow cell; negative regulation of cellular senescence; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within mitotic cell cycle. Located in chromatin. Is expressed in several structures, including alimentary system; hindlimb interdigital region; integumental system; nervous system; and skeleton. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 28.3), cortex adult (RPKM 24.4) and 22 other tissues See more
    Orthologs
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    Genomic context

    See Plk2 in Genome Data Viewer
    Location:
    13 61.97 cM; 13 D2.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (110531578..110537378)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (110395044..110400844)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:111158859-111159160 Neighboring gene predicted gene, 41058 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111172985-111173286 Neighboring gene Grb2-binding adaptor, transmembrane Neighboring gene STARR-seq mESC enhancer starr_35639 Neighboring gene STARR-seq mESC enhancer starr_35640 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111352690-111352991 Neighboring gene predicted gene, 32990 Neighboring gene STARR-positive B cell enhancer mm9_chr13:111399586-111399887 Neighboring gene STARR-seq mESC enhancer starr_35641 Neighboring gene predicted gene, 33045

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent protein binding  
    enables ATP-dependent protein binding  
    enables ATPase binding  
    enables GTPase binding  
    enables clathrin heavy chain binding  
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding  
    Items 1 - 25 of 40
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in G1/S transition of mitotic cell cycle  
    involved_in Rap protein signal transduction  
    involved_in Rap protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in long-term synaptic depression  
    involved_in long-term synaptic depression  
    involved_in long-term synaptic potentiation  
    involved_in long-term synaptic potentiation  
    involved_in memory PubMed 
    acts_upstream_of_or_within mitotic cell cycle PubMed 
    involved_in mitotic spindle organization  
    involved_in mitotic spindle organization PubMed 
    involved_in mitotic spindle organization  
    involved_in mitotic spindle organization  
    involved_in negative regulation of angiogenesis PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process in bone marrow cell PubMed 
    involved_in negative regulation of cellular senescence PubMed 
    involved_in negative regulation of dendritic spine development  
    involved_in negative regulation of excitatory postsynaptic potential  
    involved_in negative regulation of protein localization to cell surface  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of cell migration involved in sprouting angiogenesis PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of protein catabolic process  
    involved_in positive regulation of receptor internalization  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    involved_in regulation of centriole replication  
    involved_in regulation of centriole replication  
    involved_in regulation of synaptic plasticity  
    involved_in regulation of synaptic plasticity PubMed 
    involved_in regulation of synaptic plasticity  
    Items 1 - 25 of 40
    Component Evidence Code Pubs
    is_active_in centriole  
    located_in centriole  
    located_in centriole  
    is_active_in centrosome  
    located_in centrosome  
    located_in centrosome  
    located_in chromatin PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in dendrite  
    located_in dendrite  
    is_active_in kinetochore  
    located_in nucleoplasm  
    is_active_in nucleus  
    is_active_in spindle pole  

    General protein information

    Preferred Names
    serine/threonine-protein kinase PLK2
    Names
    PLK-2
    serine/threonine-protein kinase SNK
    serum-inducible kinase
    NP_690017.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152804.2NP_690017.2  serine/threonine-protein kinase PLK2

      See identical proteins and their annotated locations for NP_690017.2

      Status: VALIDATED

      Source sequence(s)
      AK160441, AK164365, BM947259, BP765662, CJ063842
      Consensus CDS
      CCDS26767.1
      UniProtKB/Swiss-Prot
      P53351
      UniProtKB/TrEMBL
      Q548A9, Q8K226
      Related
      ENSMUSP00000022212.8, ENSMUST00000022212.9
      Conserved Domains (4) summary
      smart00220
      Location:79331
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd13117
      Location:598679
      POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd13118
      Location:500585
      POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5
      cd14188
      Location:77331
      STKc_PLK2; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      110531578..110537378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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