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    ZNF77 zinc finger protein 77 [ Homo sapiens (human) ]

    Gene ID: 58492, updated on 10-Dec-2024

    Summary

    Official Symbol
    ZNF77provided by HGNC
    Official Full Name
    zinc finger protein 77provided by HGNC
    Primary source
    HGNC:HGNC:13150
    See related
    Ensembl:ENSG00000175691 MIM:194551; AllianceGenome:HGNC:13150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    pT1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 1.9), testis (RPKM 1.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ZNF77 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2933218..2944971, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2906814..2918459, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2933216..2944969, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 57 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2900543-2901114 Neighboring gene zinc finger protein 57 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982456-2982974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2982975-2983491 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr19:2984010-2984526 Neighboring gene TLE family member 6, subcortical maternal complex member Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3003179-3003325 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:3006113-3007047 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3007156-3007353 Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9820 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9821 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:3041680-3041803

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 77
    Names
    ZNFpT1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001426550.1NP_001413479.1  zinc finger protein 77 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006277, AC011559
    2. NM_001426551.1NP_001413480.1  zinc finger protein 77 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CP068259
    3. NM_021217.3NP_067040.1  zinc finger protein 77 isoform 1

      See identical proteins and their annotated locations for NP_067040.1

      Status: VALIDATED

      Source sequence(s)
      AC006277, AC011559
      Consensus CDS
      CCDS12099.1
      UniProtKB/Swiss-Prot
      Q15935, Q86XJ3, Q9NPP0
      Related
      ENSP00000319053.3, ENST00000314531.5
      Conserved Domains (3) summary
      COG5048
      Location:237544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:410430
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:444
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      2933218..2944971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      2906814..2918459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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