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    AMOT angiomotin [ Homo sapiens (human) ]

    Gene ID: 154796, updated on 10-Dec-2024

    Summary

    Official Symbol
    AMOTprovided by HGNC
    Official Full Name
    angiomotinprovided by HGNC
    Primary source
    HGNC:HGNC:17810
    See related
    Ensembl:ENSG00000126016 MIM:300410; AllianceGenome:HGNC:17810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in placenta (RPKM 13.4), brain (RPKM 9.3) and 21 other tissues See more
    Orthologs
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    Genomic context

    See AMOT in Genome Data Viewer
    Location:
    Xq23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (112774877..112840831, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (111226753..111292678, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (112018105..112084059, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29863 Neighboring gene LHFPL tetraspan subfamily member 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:111911869-111912514 Neighboring gene high mobility group box 3 pseudogene 30 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:111981774-111982356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:112022621-112023121 Neighboring gene microRNA 4329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20945 Neighboring gene uncharacterized LOC107985651 Neighboring gene NANOG hESC enhancer GRCh37_chrX:112094284-112095066 Neighboring gene RNA, 7SL, cytoplasmic 266, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of angiomotin (AMOT) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
    Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Angiomotin (AMOT) depletion inhibits HIV-1 Gag release from cells, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
    gag Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner from 293T, HeLa, and Jurkat cells PubMed
    gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1071

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables angiostatin binding PubMed 
    enables protein binding PubMed 
    enables signaling receptor activity  
    enables signaling receptor activity PubMed 
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization PubMed 
    involved_in angiogenesis  
    involved_in blood vessel endothelial cell migration  
    involved_in cell migration involved in gastrulation  
    involved_in cell-cell junction assembly PubMed 
    involved_in chemotaxis  
    involved_in establishment of cell polarity involved in ameboidal cell migration  
    involved_in establishment of epithelial cell polarity  
    involved_in gastrulation with mouth forming second  
    involved_in hippo signaling  
    acts_upstream_of_or_within hippo signaling PubMed 
    involved_in in utero embryonic development  
    acts_upstream_of_or_within negative regulation of angiogenesis PubMed 
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in negative regulation of vascular permeability PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration PubMed 
    involved_in positive regulation of cell size PubMed 
    involved_in positive regulation of embryonic development  
    involved_in positive regulation of stress fiber assembly PubMed 
    involved_in protein localization  
    involved_in regulation of cell migration  
    acts_upstream_of_or_within regulation of cell migration PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton  
    involved_in regulation of small GTPase mediated signal transduction  
    involved_in vasculogenesis  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    part_of COP9 signalosome PubMed 
    located_in actin filament PubMed 
    is_active_in bicellular tight junction  
    located_in bicellular tight junction PubMed 
    located_in cell junction  
    located_in cell surface PubMed 
    located_in cytoplasm PubMed 
    is_active_in cytoplasmic vesicle  
    located_in cytosol  
    located_in endocytic vesicle PubMed 
    located_in external side of plasma membrane PubMed 
    located_in glutamatergic synapse  
    is_active_in lamellipodium  
    located_in lamellipodium PubMed 
    located_in membrane PubMed 
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in postsynaptic density  
    located_in ruffle PubMed 
    located_in stress fiber PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012628.1 RefSeqGene

      Range
      4985..70939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001113490.2NP_001106962.1  angiomotin isoform 1

      See identical proteins and their annotated locations for NP_001106962.1

      Status: REVIEWED

      Source sequence(s)
      AC004827
      Consensus CDS
      CCDS48154.1
      UniProtKB/Swiss-Prot
      Q4VCS5, Q504X5, Q9HD27, Q9UPT1
      Related
      ENSP00000361027.3, ENST00000371959.9
      Conserved Domains (3) summary
      COG1196
      Location:431676
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:191328
      PRK10263; DNA translocase FtsK; Provisional
      pfam12240
      Location:599806
      Angiomotin_C; Angiomotin C terminal
    2. NM_001386998.1NP_001373927.1  angiomotin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004827
      Consensus CDS
      CCDS48154.1
      UniProtKB/Swiss-Prot
      Q4VCS5, Q504X5, Q9HD27, Q9UPT1
      Conserved Domains (3) summary
      COG1196
      Location:431676
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:191328
      PRK10263; DNA translocase FtsK; Provisional
      pfam12240
      Location:599806
      Angiomotin_C; Angiomotin C terminal
    3. NM_001386999.1NP_001373928.1  angiomotin isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC004827
      Consensus CDS
      CCDS48154.1
      UniProtKB/Swiss-Prot
      Q4VCS5, Q504X5, Q9HD27, Q9UPT1
      Conserved Domains (3) summary
      COG1196
      Location:431676
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:191328
      PRK10263; DNA translocase FtsK; Provisional
      pfam12240
      Location:599806
      Angiomotin_C; Angiomotin C terminal
    4. NM_133265.5NP_573572.1  angiomotin isoform 2

      See identical proteins and their annotated locations for NP_573572.1

      Status: REVIEWED

      Source sequence(s)
      AC004827
      Consensus CDS
      CCDS14563.1
      UniProtKB/TrEMBL
      A2BDD9
      Related
      ENSP00000305557.1, ENST00000304758.5
      Conserved Domains (1) summary
      pfam12240
      Location:190393
      Angiomotin_C; Angiomotin C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      112774877..112840831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441856.1XP_047297812.1  angiomotin isoform X1

      UniProtKB/Swiss-Prot
      Q4VCS5, Q504X5, Q9HD27, Q9UPT1
    2. XM_047441857.1XP_047297813.1  angiomotin isoform X1

      UniProtKB/Swiss-Prot
      Q4VCS5, Q504X5, Q9HD27, Q9UPT1
    3. XM_005262090.1XP_005262147.1  angiomotin isoform X2

      See identical proteins and their annotated locations for XP_005262147.1

      UniProtKB/TrEMBL
      A2BDD9
      Conserved Domains (1) summary
      pfam12240
      Location:190393
      Angiomotin_C; Angiomotin C terminal

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      111226753..111292678 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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