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    DUSP11 dual specificity phosphatase 11 [ Homo sapiens (human) ]

    Gene ID: 8446, updated on 10-Dec-2024

    Summary

    Official Symbol
    DUSP11provided by HGNC
    Official Full Name
    dual specificity phosphatase 11provided by HGNC
    Primary source
    HGNC:HGNC:3066
    See related
    Ensembl:ENSG00000144048 MIM:603092; AllianceGenome:HGNC:3066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIR1
    Summary
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
    Expression
    Ubiquitous expression in esophagus (RPKM 14.8), urinary bladder (RPKM 12.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DUSP11 in Genome Data Viewer
    Location:
    2p13.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73762213..73780149, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73775309..73793243, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73989340..74007276, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16031 Neighboring gene TP53RK binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr2:73981125-73981308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16034 Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74055859-74056077 Neighboring gene STAM binding protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
    EBI GWAS Catalog
    Genetic loci influencing kidney function and chronic kidney disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of dual specificity phosphatase 11 (RNA/RNP complex 1-interacting, DUSP11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Potential readthrough

    Included gene: TPRKB

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in fibrillar center  
    located_in intercellular bridge  
    located_in mitochondrion PubMed 
    located_in nuclear speck PubMed 
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    RNA/RNP complex-1-interacting phosphatase
    Names
    RNA/RNP complex 1-interacting
    RNA/RNP complex-interacting phosphatase
    dual specificity protein phosphatase 11
    phosphatase that interacts with RNA/RNP complex 1
    serine/threonine specific protein phosphatase
    NP_001411578.1
    NP_003575.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424649.1NP_001411578.1  RNA/RNP complex-1-interacting phosphatase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This transcript variant (2) uses upstream transcription and translation start sites compared to transcript variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AC092653
      UniProtKB/TrEMBL
      A0A8Q3SIB0
      Related
      ENSP00000520634.1, ENST00000717658.1
    2. NM_003584.3NP_003575.3  RNA/RNP complex-1-interacting phosphatase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This transcript variant (1) encodes isoform 1.
      Source sequence(s)
      AC092653
      Consensus CDS
      CCDS1928.3
      UniProtKB/Swiss-Prot
      B2RCT8, C9JYA6, O75319, Q6AI47, Q9BWE3
      UniProtKB/TrEMBL
      A0A8Q3SIB0
      Related
      ENSP00000272444.4, ENST00000272444.8
      Conserved Domains (1) summary
      cd17665
      Location:34201
      DSP_DUSP11; dual-specificity phosphatase domain of dual specificity protein phosphatase 11 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      73762213..73780149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791766.1 Reference GRCh38.p14 PATCHES

      Range
      431711..449647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      73775309..73793243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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