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Ulk4 unc-51-like kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 209012, updated on 9-Dec-2024

Summary

Official Symbol
Ulk4provided by MGI
Official Full Name
unc-51-like kinase 4provided by MGI
Primary source
MGI:MGI:1921622
See related
Ensembl:ENSMUSG00000040936 AllianceGenome:MGI:1921622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A730098P15; 4932415A06Rik
Summary
Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Acts upstream of or within several processes, including adult walking behavior; cilium organization; and nervous system development. Is active in cilium. Is expressed in brain. Used to study hydrocephalus and schizophrenia. Orthologous to human ULK4 (unc-51 like kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 56.7) and ovary adult (RPKM 3.4) See more
Orthologs
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Genomic context

See Ulk4 in Genome Data Viewer
Location:
9 F4; 9 72.19 cM
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (120793520..121115225, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (120964454..121286159, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930593C16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:120870733-120870842 Neighboring gene predicted gene, 38502 Neighboring gene STARR-seq mESC enhancer starr_25518 Neighboring gene catenin beta 1 Neighboring gene microRNA 7090 Neighboring gene predicted gene, 34945 Neighboring gene zinc finger protein 606 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2313 Neighboring gene STARR-positive B cell enhancer ABC_E3868 Neighboring gene predicted gene, 34735 Neighboring gene VISTA enhancer mm1661 Neighboring gene predicted gene, 34655 Neighboring gene STARR-seq mESC enhancer starr_25526 Neighboring gene STARR-seq mESC enhancer starr_25527 Neighboring gene trafficking protein, kinesin binding 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121280653-121280762 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121388759-121388868 Neighboring gene predicted gene, 51661 Neighboring gene predicted gene, 38661 Neighboring gene cholecystokinin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity  
enables AMP-activated protein kinase activity  
enables ATP binding  
enables DNA-dependent protein kinase activity  
enables Rho-dependent protein serine/threonine kinase activity  
enables eukaryotic translation initiation factor 2alpha kinase activity  
enables histone H2AS1 kinase activity  
enables histone H2AS121 kinase activity  
enables histone H2AT120 kinase activity  
enables histone H2AXS139 kinase activity  
enables histone H2BS14 kinase activity  
enables histone H2BS36 kinase activity  
enables histone H3S10 kinase activity  
enables histone H3S28 kinase activity  
enables histone H3S57 kinase activity  
enables histone H3T11 kinase activity  
enables histone H3T3 kinase activity  
enables histone H3T45 kinase activity  
enables histone H3T6 kinase activity  
enables histone H4S1 kinase activity  
enables protein serine kinase activity  
enables ribosomal protein S6 kinase activity  
Items 1 - 25 of 39
Process Evidence Code Pubs
acts_upstream_of_or_within GABAergic neuron differentiation PubMed 
acts_upstream_of_or_within adult behavior PubMed 
acts_upstream_of_or_within adult walking behavior PubMed 
acts_upstream_of_or_within axoneme assembly PubMed 
acts_upstream_of_or_within brain development PubMed 
acts_upstream_of_or_within central nervous system myelination PubMed 
acts_upstream_of_or_within cerebral cortex development PubMed 
acts_upstream_of_or_within cerebrospinal fluid circulation PubMed 
involved_in chromatin remodeling  
acts_upstream_of_or_within ciliary basal body organization PubMed 
acts_upstream_of_or_within cognition PubMed 
acts_upstream_of_or_within corpus callosum development PubMed 
acts_upstream_of_or_within dendritic spine development PubMed 
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement PubMed 
acts_upstream_of_or_within establishment of localization in cell PubMed 
acts_upstream_of_or_within gene expression PubMed 
acts_upstream_of_or_within layer formation in cerebral cortex PubMed 
acts_upstream_of_or_within learning or memory PubMed 
acts_upstream_of_or_within memory PubMed 
acts_upstream_of_or_within microtubule cytoskeleton organization  
acts_upstream_of_or_within motile cilium assembly PubMed 
acts_upstream_of_or_within neurogenesis PubMed 
acts_upstream_of_or_within neuroinflammatory response PubMed 
acts_upstream_of_or_within neuronal stem cell division PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
acts_upstream_of_or_within protein kinase C deactivation  
acts_upstream_of_or_within pyramidal neuron differentiation PubMed 
acts_upstream_of_or_within regulation of JNK cascade  
acts_upstream_of_or_within regulation of MAPK cascade  
acts_upstream_of_or_within regulation of neuron migration  
acts_upstream_of_or_within regulation of neuron projection development  
acts_upstream_of_or_within regulation of p38MAPK cascade  
acts_upstream_of_or_within regulation of protein-containing complex assembly PubMed 
acts_upstream_of_or_within regulation of signal transduction PubMed 
acts_upstream_of_or_within regulation of tau-protein kinase activity PubMed 
acts_upstream_of_or_within sensory perception PubMed 
acts_upstream_of_or_within smoothened signaling pathway PubMed 
acts_upstream_of_or_within social behavior PubMed 
acts_upstream_of_or_within ventricular system development PubMed 
Items 1 - 25 of 39
Component Evidence Code Pubs
is_active_in cellular_component  
is_active_in cilium PubMed 
located_in extracellular region  

General protein information

Preferred Names
serine/threonine-protein kinase ULK4
NP_808257.2
XP_006512086.1
XP_006512087.1
XP_006512088.1
XP_006512089.1
XP_011241254.1
XP_017168752.1
XP_030100042.1
XP_030100043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177589.3NP_808257.2  serine/threonine-protein kinase ULK4

    Status: VALIDATED

    Source sequence(s)
    AK132731, AW456669, BC065094, BM938704
    Consensus CDS
    CCDS52967.1
    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    UniProtKB/TrEMBL
    E9Q2P5
    Related
    ENSMUSP00000131342.2, ENSMUST00000171923.8
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    120793520..121115225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512024.4XP_006512087.1  serine/threonine-protein kinase ULK4 isoform X1

    See identical proteins and their annotated locations for XP_006512087.1

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  2. XM_030244183.2XP_030100043.1  serine/threonine-protein kinase ULK4 isoform X2

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    UniProtKB/TrEMBL
    E9Q2P5
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  3. XM_030244182.1XP_030100042.1  serine/threonine-protein kinase ULK4 isoform X2

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    UniProtKB/TrEMBL
    E9Q2P5
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  4. XM_006512023.3XP_006512086.1  serine/threonine-protein kinase ULK4 isoform X1

    See identical proteins and their annotated locations for XP_006512086.1

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  5. XM_017313263.3XP_017168752.1  serine/threonine-protein kinase ULK4 isoform X1

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  6. XM_006512025.5XP_006512088.1  serine/threonine-protein kinase ULK4 isoform X3

    UniProtKB/Swiss-Prot
    Q2VP87, Q32LZ6, Q3V129, Q8BLS0, Q8C8Z5, Q9D4H6
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
  7. XM_006512026.4XP_006512089.1  serine/threonine-protein kinase ULK4 isoform X5

  8. XM_011242952.4XP_011241254.1  serine/threonine-protein kinase ULK4 isoform X4

    Related
    ENSMUSP00000129214.2, ENSMUST00000171061.8
    Conserved Domains (1) summary
    cd14010
    Location:3280
    STKc_ULK4; Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4
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