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    Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 14396, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gabra3provided by MGI
    Official Full Name
    gamma-aminobutyric acid type A receptor subunit alpha 3provided by MGI
    Primary source
    MGI:MGI:95615
    See related
    Ensembl:ENSMUSG00000031343 AllianceGenome:MGI:95615
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gabra-3
    Summary
    Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in bipolar disorder and multiple sclerosis. Orthologous to human GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 17.8), cortex adult (RPKM 14.7) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gabra3 in Genome Data Viewer
    Location:
    X A7.3; X 37.24 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71476282..71700525, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72432676..72656919, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 452 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene STARR-seq mESC enhancer starr_47334 Neighboring gene MAGE family member A10 Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47335 Neighboring gene STARR-seq mESC enhancer starr_47336 Neighboring gene STARR-seq mESC enhancer starr_47337 Neighboring gene microRNA 767 Neighboring gene microRNA 105 Neighboring gene predicted gene, 23461 Neighboring gene STARR-seq mESC enhancer starr_47338 Neighboring gene predicted gene, 57671 Neighboring gene STARR-seq mESC enhancer starr_47339 Neighboring gene gamma-aminobutyric acid type A receptor subunit theta

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in chemical synaptic transmission  
    involved_in chloride transmembrane transport  
    involved_in chloride transmembrane transport  
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in gamma-aminobutyric acid signaling pathway  
    involved_in inhibitory synapse assembly  
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of postsynaptic membrane potential  
    involved_in synaptic transmission, GABAergic  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex  
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse  
    part_of chloride channel complex  
    is_active_in dendrite membrane  
    is_active_in postsynapse  
    is_active_in postsynaptic specialization membrane PubMed 
    is_active_in postsynaptic specialization membrane  
    is_active_in presynaptic active zone membrane  
    is_active_in synapse  

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-3
    Names
    GABA(A) receptor subunit alpha-3
    GABAAR subunit alpha-3
    gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357814.1NP_001344743.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL731695, BX119994
      Consensus CDS
      CCDS30187.1
      UniProtKB/Swiss-Prot
      P26049
      UniProtKB/TrEMBL
      Q8CAB3
      Related
      ENSMUSP00000110201.3, ENSMUST00000114554.3
      Conserved Domains (2) summary
      TIGR00860
      Location:69478
      LIC; Cation transporter family protein
      cd19036
      Location:75274
      LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
    2. NM_001357815.1NP_001344744.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL731695, BX119994
      UniProtKB/TrEMBL
      Q8CAB3
      Conserved Domains (1) summary
      cl27321
      Location:83492
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    3. NM_001357816.1NP_001344745.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL731695, BX119994
      UniProtKB/TrEMBL
      B1AVY2
      Conserved Domains (1) summary
      cl27321
      Location:100509
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    4. NM_001358103.1NP_001345032.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AL731695, BX119994
      Consensus CDS
      CCDS30187.1
      UniProtKB/Swiss-Prot
      P26049
      UniProtKB/TrEMBL
      Q8CAB3
      Conserved Domains (2) summary
      TIGR00860
      Location:69478
      LIC; Cation transporter family protein
      cd19036
      Location:75274
      LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
    5. NM_008067.4NP_032093.3  gamma-aminobutyric acid receptor subunit alpha-3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032093.3

      Status: VALIDATED

      Source sequence(s)
      AK039144, AK134760, AL731695, BX119994, CD354278
      Consensus CDS
      CCDS30187.1
      UniProtKB/Swiss-Prot
      P26049
      UniProtKB/TrEMBL
      Q8CAB3
      Related
      ENSMUSP00000062638.7, ENSMUST00000055966.13
      Conserved Domains (2) summary
      TIGR00860
      Location:69478
      LIC; Cation transporter family protein
      cd19036
      Location:75274
      LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      71476282..71700525 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161818.1XP_036017711.1  gamma-aminobutyric acid receptor subunit alpha-3 isoform X1

      UniProtKB/Swiss-Prot
      P26049
      UniProtKB/TrEMBL
      Q8CAB3
      Conserved Domains (2) summary
      TIGR00860
      Location:69478
      LIC; Cation transporter family protein
      cd19036
      Location:75274
      LGIC_ECD_GABAAR_A3; extracellular domain of gamma-aminobutyric acid receptor subunit alpha-3 (GABAAR-A3 or GABRA3)
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