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    Pkn1 protein kinase N1 [ Mus musculus (house mouse) ]

    Gene ID: 320795, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pkn1provided by MGI
    Official Full Name
    protein kinase N1provided by MGI
    Primary source
    MGI:MGI:108022
    See related
    Ensembl:ENSMUSG00000057672 AllianceGenome:MGI:108022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DBK; Pkn; PAK1; PRK1; Stk3; Prkcl1; F730027O18Rik
    Summary
    Enables protein kinase activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; regulation of germinal center formation; and spleen development. Located in cytoplasmic vesicle. Is expressed in several structures, including brown fat; genitourinary system; gut; nervous system; and vascular system. Orthologous to human PKN1 (protein kinase N1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 55.4), spleen adult (RPKM 49.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pkn1 in Genome Data Viewer
    Location:
    8 C2; 8 40.22 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84393162..84425819, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83666533..83699181, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member B1 Neighboring gene STARR-seq mESC enhancer starr_22093 Neighboring gene STARR-positive B cell enhancer ABC_E1372 Neighboring gene STARR-positive B cell enhancer ABC_E11744 Neighboring gene GIPC PDZ domain containing family, member 1 Neighboring gene prostaglandin E receptor 1 (subtype EP1) Neighboring gene STARR-positive B cell enhancer ABC_E9319 Neighboring gene STARR-seq mESC enhancer starr_22095 Neighboring gene STARR-positive B cell enhancer ABC_E562 Neighboring gene DEAD box helicase 39a Neighboring gene microRNA 1668 Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86260655-86260859 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:86263836-86264037 Neighboring gene predicted gene, 46046

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ATP binding  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity  
    enables chromatin binding  
    enables chromatin binding  
    enables diacylglycerol-dependent serine/threonine kinase activity  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone binding  
    enables histone binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables nuclear androgen receptor binding  
    enables nuclear androgen receptor binding  
    enables nuclear receptor coactivator activity  
    enables nuclear receptor coactivator activity  
    enables protein binding PubMed 
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables small GTPase binding  
    enables small GTPase binding  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell apoptotic process PubMed 
    acts_upstream_of_or_within B cell homeostasis PubMed 
    involved_in chromatin remodeling  
    involved_in epithelial cell migration  
    involved_in epithelial cell migration  
    acts_upstream_of_or_within hyperosmotic response PubMed 
    involved_in intracellular signal transduction  
    acts_upstream_of_or_within negative regulation of B cell proliferation PubMed 
    acts_upstream_of_or_within negative regulation of protein kinase activity PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation PubMed 
    involved_in positive regulation of DNA-templated transcription  
    involved_in post-translational protein modification  
    involved_in post-translational protein modification  
    involved_in protein phosphorylation  
    involved_in regulation of cell motility  
    involved_in regulation of cell motility  
    acts_upstream_of_or_within regulation of germinal center formation PubMed 
    acts_upstream_of_or_within regulation of immunoglobulin production PubMed 
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within renal system process PubMed 
    involved_in signal transduction  
    acts_upstream_of_or_within spleen development PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic vesicle PubMed 
    located_in endosome  
    located_in endosome  
    located_in midbody  
    located_in midbody  
    located_in nucleus  
    located_in nucleus  
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase N1
    Names
    protein kinase C-like 1
    protein kinase C-like PKN
    protein-kinase C-related kinase 1
    serine-threonine protein kinase N
    serine/threonine kinase 3
    NP_001186522.1
    NP_796236.2
    XP_030099481.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199593.1NP_001186522.1  serine/threonine-protein kinase N1 isoform 1

      See identical proteins and their annotated locations for NP_001186522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC164432, AK089431, AK149649, CX568360
      Consensus CDS
      CCDS57627.1
      UniProtKB/Swiss-Prot
      P70268
      Related
      ENSMUSP00000116235.2, ENSMUST00000144258.8
      Conserved Domains (5) summary
      cd08687
      Location:397484
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:37103
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:126197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:624948
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:214286
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
    2. NM_177262.4NP_796236.2  serine/threonine-protein kinase N1 isoform 2

      See identical proteins and their annotated locations for NP_796236.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC164432, BC052923, CX568360
      Consensus CDS
      CCDS22459.1
      UniProtKB/Swiss-Prot
      P70268, Q3UEA6, Q7TST2, Q8BTL8
      Related
      ENSMUSP00000005616.9, ENSMUST00000005616.16
      Conserved Domains (6) summary
      PTZ00263
      Location:616939
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd08687
      Location:392479
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:3298
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:121192
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:619943
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:209281
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84393162..84425819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243621.2XP_030099481.1  serine/threonine-protein kinase N1 isoform X1

      Conserved Domains (5) summary
      cd08687
      Location:397484
      C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
      cd11622
      Location:37103
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd11630
      Location:126197
      HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
      cd05589
      Location:624948
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:214286
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases

    RNA

    1. XR_004934844.1 RNA Sequence

    2. XR_004934845.1 RNA Sequence

    3. XR_004934843.1 RNA Sequence

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