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SLFN5 schlafen family member 5 [ Homo sapiens (human) ]

Gene ID: 162394, updated on 10-Dec-2024

Summary

Official Symbol
SLFN5provided by HGNC
Official Full Name
schlafen family member 5provided by HGNC
Primary source
HGNC:HGNC:28286
See related
Ensembl:ENSG00000166750 MIM:614952; AllianceGenome:HGNC:28286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ATP binding activity. Predicted to be involved in cell differentiation. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in lymph node (RPKM 15.8), urinary bladder (RPKM 14.2) and 24 other tissues See more
Orthologs
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Genomic context

See SLFN5 in Genome Data Viewer
Location:
17q12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (35243072..35273655)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (36191007..36221590)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (33570091..33600674)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35 member G3 Neighboring gene Spi-C transcription factor pseudogene 2 Neighboring gene uncharacterized LOC105371932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12060 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:33570506-33571134 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:33583732-33584931 Neighboring gene NANOG hESC enhancer GRCh37_chr17:33638706-33639207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33640386-33641045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:33641707-33642365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660479-33660980 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:33660981-33661480 Neighboring gene RING-box protein 2-like Neighboring gene schlafen family member 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12063 Neighboring gene uncharacterized LOC105371933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12064

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif interacts with SLFN5 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

General gene information

Clone Names

  • MGC19764, MGC150611, MGC150612

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding  
Component Evidence Code Pubs
located_in nucleus  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330183.2NP_001317112.1  schlafen family member 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC022706, AK303632, BQ023439
    Consensus CDS
    CCDS82106.1
    UniProtKB/TrEMBL
    B4E128
    Related
    ENSP00000440537.1, ENST00000542451.1
  2. NM_144975.4NP_659412.3  schlafen family member 5 isoform 1

    See identical proteins and their annotated locations for NP_659412.3

    Status: VALIDATED

    Source sequence(s)
    AC022706, BC125200, BP281007, BX102817
    Consensus CDS
    CCDS32619.1
    UniProtKB/Swiss-Prot
    Q08AF2, Q08AF3, Q8WU54, Q96A82
    UniProtKB/TrEMBL
    B4E0B1
    Related
    ENSP00000299977.3, ENST00000299977.9
    Conserved Domains (3) summary
    cl21455
    Location:574657
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:839886
    UvrD_C_2; UvrD-like helicase C-terminal domain
    cl27772
    Location:34332
    B3R; Poxviridae B3 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    35243072..35273655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    36191007..36221590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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