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Adsl adenylosuccinate lyase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315150, updated on 9-Dec-2024

Summary

Official Symbol
Adslprovided by RGD
Official Full Name
adenylosuccinate lyaseprovided by RGD
Primary source
RGD:1307617
See related
EnsemblRapid:ENSRNOG00000018655 AllianceGenome:RGD:1307617
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity; and identical protein binding activity. Involved in several processes, including AMP biosynthetic process; response to hypoxia; and response to muscle activity. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Biomarker of breast cancer. Human ortholog(s) of this gene implicated in adenylosuccinase lyase deficiency. Orthologous to human ADSL (adenylosuccinate lyase). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Muscle (RPKM 502.4), Heart (RPKM 220.5) and 9 other tissues See more
Orthologs
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Genomic context

See Adsl in Genome Data Viewer
Location:
7q34
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (114359440..114383618)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112479256..112503439)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (122157201..122192328)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing adaptor 6B Neighboring gene uncharacterized LOC120093695 Neighboring gene ribosomal protein L29, pseudogene 1 Neighboring gene SREK1-interacting protein 1, pseudogene 1 Neighboring gene small G protein signaling modulator 3 Neighboring gene myocardin related transcription factor A

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in 'de novo' AMP biosynthetic process  
involved_in 'de novo' AMP biosynthetic process  
involved_in 'de novo' AMP biosynthetic process  
involved_in 'de novo' IMP biosynthetic process  
involved_in 'de novo' IMP biosynthetic process  
involved_in 'de novo' XMP biosynthetic process  
involved_in AMP biosynthetic process PubMed 
involved_in AMP biosynthetic process  
involved_in AMP salvage  
involved_in GMP biosynthetic process  
involved_in aerobic respiration PubMed 
involved_in response to hypoxia PubMed 
involved_in response to muscle activity PubMed 
involved_in response to nutrient PubMed 
involved_in response to starvation PubMed 
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
part_of protein-containing complex  

General protein information

Preferred Names
adenylosuccinate lyase
NP_001123975.1
XP_063119688.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130503.1NP_001123975.1  adenylosuccinate lyase

    See identical proteins and their annotated locations for NP_001123975.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473950
    UniProtKB/TrEMBL
    A0A8I5ZTN5, A0A8I6GJ79, A6HSY1
    Related
    ENSRNOP00000081561.1, ENSRNOT00000110086.2
    Conserved Domains (2) summary
    cd03302
    Location:17452
    Adenylsuccinate_lyase_2; Adenylsuccinate lyase (ASL)_subgroup 2
    TIGR00928
    Location:17460
    purB; adenylosuccinate lyase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    114359440..114383618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263618.1XP_063119688.1  adenylosuccinate lyase isoform X1

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