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    ARL4D ARF like GTPase 4D [ Homo sapiens (human) ]

    Gene ID: 379, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARL4Dprovided by HGNC
    Official Full Name
    ARF like GTPase 4Dprovided by HGNC
    Primary source
    HGNC:HGNC:656
    See related
    Ensembl:ENSG00000175906 MIM:600732; AllianceGenome:HGNC:656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARF4L
    Summary
    ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusually high guanine nucleotide exchange rate. This protein may play a role in membrane-associated intracellular trafficking. [provided by RefSeq, Jul 2021]
    Expression
    Broad expression in thyroid (RPKM 16.5), esophagus (RPKM 15.6) and 20 other tissues See more
    Orthologs
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    Genomic context

    See ARL4D in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43398993..43401137)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44248757..44250901)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41476361..41478505)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 910 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41464317-41464832 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41464833-41465348 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41465639-41466392 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41466393-41467146 Neighboring gene RNA, U2 small nuclear 4, pseudogene Neighboring gene RNA, U6 small nuclear 1137, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41476485-41476988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41483740-41484240 Neighboring gene RNA, U6 small nuclear 470, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:41495953-41496764 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:41516034-41516798 Neighboring gene MIR2117 host gene Neighboring gene microRNA 2117

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTP binding  
    enables GTPase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in intracellular protein transport  
    involved_in protein secretion PubMed 
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in nucleolus  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 4D
    Names
    ADP ribosylation factor like GTPase 4D
    ADP-ribosylation factor-like 4D
    ADP-ribosylation factor-like protein 4L

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001661.4NP_001652.2  ADP-ribosylation factor-like protein 4D

      See identical proteins and their annotated locations for NP_001652.2

      Status: REVIEWED

      Source sequence(s)
      AC087650, BC000043, BI547763, BM682844
      Consensus CDS
      CCDS11463.1
      UniProtKB/Swiss-Prot
      B2RC59, D3DX43, P49703
      Related
      ENSP00000322628.2, ENST00000320033.5
      Conserved Domains (1) summary
      cl38936
      Location:19201
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      43398993..43401137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524782.3XP_011523084.1  ADP-ribosylation factor-like protein 4D isoform X1

      See identical proteins and their annotated locations for XP_011523084.1

      UniProtKB/Swiss-Prot
      B2RC59, D3DX43, P49703
      Conserved Domains (1) summary
      cl38936
      Location:19201
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      44248757..44250901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316021.1XP_054171996.1  ADP-ribosylation factor-like protein 4D isoform X1

      UniProtKB/Swiss-Prot
      B2RC59, D3DX43, P49703
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