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    Odad4 outer dynein arm complex subunit 4 [ Mus musculus (house mouse) ]

    Gene ID: 74407, updated on 9-Dec-2024

    Summary

    Official Symbol
    Odad4provided by MGI
    Official Full Name
    outer dynein arm complex subunit 4provided by MGI
    Primary source
    MGI:MGI:1921657
    See related
    Ensembl:ENSMUSG00000006784 AllianceGenome:MGI:1921657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ttc25; 4933404O19Rik
    Summary
    Acts upstream of or within brain development; epithelial cilium movement involved in extracellular fluid movement; and outer dynein arm assembly. Located in 9+0 motile cilium; 9+2 motile cilium; and axoneme. Is expressed in node. Used to study primary ciliary dyskinesia 35. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 35. Orthologous to human ODAD4 (outer dynein arm docking complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 18.4) and lung adult (RPKM 0.7) See more
    Orthologs
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    Genomic context

    See Odad4 in Genome Data Viewer
    Location:
    11 D; 11 63.47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100436434..100463392)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100545608..100572566)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene microRNA 7116 Neighboring gene ATP citrate lyase Neighboring gene STARR-positive B cell enhancer ABC_E3021 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GGA) Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene DnaJ heat shock protein family (Hsp40) member C7 Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene NFKB inhibitor interacting Ras-like protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in 9+0 motile cilium PubMed 
    located_in 9+2 motile cilium PubMed 
    located_in axoneme PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in extracellular region  
    part_of outer dynein arm docking complex  

    General protein information

    Preferred Names
    outer dynein arm-docking complex subunit 4
    Names
    TPR repeat protein 25
    tetratricopeptide repeat domain 25
    tetratricopeptide repeat protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363174.1NP_001350103.1  outer dynein arm-docking complex subunit 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK161541, BX842667
      Consensus CDS
      CCDS88255.1
      UniProtKB/TrEMBL
      B8A5X0
      Related
      ENSMUSP00000006976.8, ENSMUST00000006976.8
      Conserved Domains (3) summary
      COG0457
      Location:244478
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:1439
      TPR; TPR repeat [structural motif]
      cl26005
      Location:1899
      PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    2. NM_028918.3NP_083194.2  outer dynein arm-docking complex subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_083194.2

      Status: VALIDATED

      Source sequence(s)
      AK016657, AK161541, BX842667, CA463990
      Consensus CDS
      CCDS36331.1
      UniProtKB/Swiss-Prot
      A2BI62, Q80X58, Q9D4B2
      Related
      ENSMUSP00000090355.6, ENSMUST00000092684.12
      Conserved Domains (3) summary
      sd00006
      Location:1439
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:1476
      TPR_11; TPR repeat
      pfam13424
      Location:396466
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      100436434..100463392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534365.5XP_006534428.1  outer dynein arm-docking complex subunit 4 isoform X1

      Conserved Domains (3) summary
      TIGR00990
      Location:1899
      3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
      sd00006
      Location:1439
      TPR; TPR repeat [structural motif]
      pfam17874
      Location:321468
      TPR_MalT; MalT-like TPR region

    RNA

    1. XR_388541.4 RNA Sequence

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