U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Acsl6 acyl-CoA synthetase long-chain family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 216739, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acsl6provided by MGI
    Official Full Name
    acyl-CoA synthetase long-chain family member 6provided by MGI
    Primary source
    MGI:MGI:894291
    See related
    Ensembl:ENSMUSG00000020333 AllianceGenome:MGI:894291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LACS; Facl6; Lacsl; mKIAA0837; A330035H04Rik
    Summary
    Enables long-chain fatty acid-CoA ligase activity. Acts upstream of or within neuroblast proliferation. Located in mitochondrion. Is expressed in heart; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 31.2), cortex adult (RPKM 27.1) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Acsl6 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54194580..54255582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54303805..54364756)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12223 Neighboring gene interleukin 3 Neighboring gene STARR-seq mESC enhancer starr_29507 Neighboring gene predicted gene, 51861 Neighboring gene predicted gene 12224 Neighboring gene meiotic kinetochore factor Neighboring gene mucolipin 2 pseudogene Neighboring gene oxidative stress responsive 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC36650

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables arachidonate-CoA ligase activity  
    enables arachidonate-CoA ligase activity  
    enables arachidonate-CoA ligase activity  
    enables enzyme binding  
    enables long-chain fatty acid-CoA ligase activity PubMed 
    enables long-chain fatty acid-CoA ligase activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in mitochondrial outer membrane  
    located_in mitochondrion PubMed 
    located_in peroxisomal membrane  

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 6
    Names
    LACS 6
    arachidonate--CoA ligase
    fatty acid Coenzyme A ligase, long chain 6
    long-chain acyl-CoA synthetase 6
    NP_001028769.1
    NP_001028770.1
    NP_001028771.1
    NP_659072.3
    XP_006532906.1
    XP_006532907.1
    XP_006532908.1
    XP_030101661.1
    XP_030101662.1
    XP_036012431.1
    XP_036012432.1
    XP_036012433.1
    XP_036012434.1
    XP_036012435.1
    XP_036012436.1
    XP_036012437.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033597.1NP_001028769.1  long-chain-fatty-acid--CoA ligase 6 isoform 2

      See identical proteins and their annotated locations for NP_001028769.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is the same length as but includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region.
      Source sequence(s)
      AL596127, AL603822, BC022959
      Consensus CDS
      CCDS24694.1
      UniProtKB/TrEMBL
      Q5ICG6, Q8R1X1
      Related
      ENSMUSP00000104532.4, ENSMUST00000108904.10
      Conserved Domains (2) summary
      PLN02736
      Location:104718
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_001033598.1NP_001028770.1  long-chain-fatty-acid--CoA ligase 6 isoform 3

      See identical proteins and their annotated locations for NP_001028770.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding region and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK147283
      Consensus CDS
      CCDS24696.1
      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Related
      ENSMUSP00000090795.6, ENSMUST00000093106.12
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. NM_001033599.1NP_001028771.1  long-chain-fatty-acid--CoA ligase 6 isoform 4

      See identical proteins and their annotated locations for NP_001028771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding region and uses a downstream start codon, and also includes an alternative in-frame exon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus and also differs in an internal region, compared to isoform 1.
      Source sequence(s)
      AL596127, AY786362, BB634066
      Consensus CDS
      CCDS24697.1
      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Related
      ENSMUSP00000098773.3, ENSMUST00000101213.9
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. NM_144823.4NP_659072.3  long-chain-fatty-acid--CoA ligase 6 isoform 1

      See identical proteins and their annotated locations for NP_659072.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      AK147421
      Consensus CDS
      CCDS24695.1
      UniProtKB/TrEMBL
      Q5F2D0, Q5ICG6
      Related
      ENSMUSP00000104533.4, ENSMUST00000108905.10
      Conserved Domains (2) summary
      PLN02736
      Location:104718
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54194580..54255582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245801.2XP_030101661.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. XM_036156542.1XP_036012435.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. XM_030245802.2XP_030101662.1  long-chain-fatty-acid--CoA ligase 6 isoform X6

      UniProtKB/TrEMBL
      Q5ICG6
      Conserved Domains (1) summary
      cd05927
      Location:141744
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. XM_036156540.1XP_036012433.1  long-chain-fatty-acid--CoA ligase 6 isoform X3

      UniProtKB/TrEMBL
      Q5ICG6
      Conserved Domains (1) summary
      cd05927
      Location:141692
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. XM_006532843.2XP_006532906.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      See identical proteins and their annotated locations for XP_006532906.1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Related
      ENSMUSP00000072040.5, ENSMUST00000072178.11
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    6. XM_036156541.1XP_036012434.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    7. XM_036156538.1XP_036012431.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    8. XM_006532844.1XP_006532907.1  long-chain-fatty-acid--CoA ligase 6 isoform X1

      See identical proteins and their annotated locations for XP_006532907.1

      UniProtKB/Swiss-Prot
      Q80ZF1, Q91WC3
      UniProtKB/TrEMBL
      A8IP90, Q5ICG4
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    9. XM_036156543.1XP_036012436.1  long-chain-fatty-acid--CoA ligase 6 isoform X4

      UniProtKB/TrEMBL
      A8IP90
      Conserved Domains (1) summary
      cd05927
      Location:116667
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    10. XM_036156539.1XP_036012432.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Related
      ENSMUSP00000098771.3, ENSMUST00000101211.9
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    11. XM_006532845.3XP_006532908.1  long-chain-fatty-acid--CoA ligase 6 isoform X2

      See identical proteins and their annotated locations for XP_006532908.1

      UniProtKB/TrEMBL
      A8IP90, Q5ICG5
      Conserved Domains (1) summary
      cd05927
      Location:116693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    12. XM_036156544.1XP_036012437.1  long-chain-fatty-acid--CoA ligase 6 isoform X5

      UniProtKB/TrEMBL
      Q80TQ7
      Conserved Domains (1) summary
      cl17068
      Location:1369
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RNA

    1. XR_004936915.1 RNA Sequence

    2. XR_003949381.2 RNA Sequence

    External link. Please review our privacy policy.