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    PTGER3 prostaglandin E receptor 3 [ Homo sapiens (human) ]

    Gene ID: 5733, updated on 10-Dec-2024

    Summary

    Official Symbol
    PTGER3provided by HGNC
    Official Full Name
    prostaglandin E receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:9595
    See related
    Ensembl:ENSG00000050628 MIM:176806; AllianceGenome:HGNC:9595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875
    Summary
    The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PTGER3 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (70852358..71047816, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70730386..70925810, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71318041..71513499, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.6877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1197 Neighboring gene caspase 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene MPRA-validated peak284 silencer Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC27302, MGC141828, MGC141829

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity  
    enables prostaglandin E receptor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in membrane PubMed 
    located_in nuclear envelope PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP3 subtype
    Names
    PGE receptor, EP3 subtype
    PGE2 receptor EP3 subtype
    prostaglandin E receptor 3 (subtype EP3)
    prostaglandin receptor (PGE-2)
    prostanoid EP3 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029509.2 RefSeqGene

      Range
      4993..82027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126044.2NP_001119516.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_001119516.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, S69326
      Consensus CDS
      CCDS656.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Conserved Domains (1) summary
      pfam00001
      Location:65346
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_198714.2NP_942007.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_942007.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D38298, X83861, X83863
      Consensus CDS
      CCDS656.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Related
      ENSP00000359969.3, ENST00000370931.7
      Conserved Domains (1) summary
      pfam00001
      Location:65346
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_198715.3NP_942008.1  prostaglandin E2 receptor EP3 subtype isoform 5

      See identical proteins and their annotated locations for NP_942008.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, D38299
      Consensus CDS
      CCDS658.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000359962.3, ENST00000370924.5
      Conserved Domains (1) summary
      cd15146
      Location:49358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
    4. NM_198716.2NP_942009.1  prostaglandin E2 receptor EP3 subtype isoform 6

      See identical proteins and their annotated locations for NP_942009.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, BC024229, X83861, X83863
      Consensus CDS
      CCDS652.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000418073.1, ENST00000460330.5
      Conserved Domains (1) summary
      cd15146
      Location:49358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
    5. NM_198717.2NP_942010.1  prostaglandin E2 receptor EP3 subtype isoform 7

      See identical proteins and their annotated locations for NP_942010.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D38301, X83861, X83863
      Consensus CDS
      CCDS44160.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000486617.1, ENST00000628037.2
      Conserved Domains (1) summary
      cd15146
      Location:49358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors
    6. NM_198718.2NP_942011.1  prostaglandin E2 receptor EP3 subtype isoform 8

      See identical proteins and their annotated locations for NP_942011.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, D86097, X83862
      Consensus CDS
      CCDS655.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000349003.4, ENST00000356595.8
      Conserved Domains (1) summary
      pfam00001
      Location:65346
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    7. NM_198719.2NP_942012.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_942012.1

      Status: REVIEWED

      Source sequence(s)
      AI273491, AL031429, D38297
      Consensus CDS
      CCDS657.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Related
      ENSP00000302313.5, ENST00000306666.10
      Conserved Domains (1) summary
      pfam00001
      Location:65346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_028292.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86097
      Related
      ENST00000361210.6
    2. NR_028293.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86098
      Related
      ENST00000479353.5
    3. NR_028294.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86097, X83863
      Related
      ENST00000497146.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      70852358..71047816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541810.4XP_011540112.1  prostaglandin E2 receptor EP3 subtype isoform X1

      UniProtKB/TrEMBL
      A8K3L9
      Conserved Domains (1) summary
      pfam00001
      Location:65346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. XR_946714.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      70730386..70925810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337808.1XP_054193783.1  prostaglandin E2 receptor EP3 subtype isoform X1

      UniProtKB/TrEMBL
      A8K3L9

    RNA

    1. XR_008486118.1 RNA Sequence

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