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Map3k20 mitogen-activated protein kinase kinase kinase 20 [ Mus musculus (house mouse) ]

Gene ID: 65964, updated on 9-Dec-2024

Summary

Official Symbol
Map3k20provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 20provided by MGI
Primary source
MGI:MGI:2443258
See related
Ensembl:ENSMUSG00000004085 AllianceGenome:MGI:2443258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRK; Zak; MLTK; HCCS-4; MLTKbeta; MLTKalpha; B230120H23Rik
Summary
Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in MAPK cascade; embryonic digit morphogenesis; and protein phosphorylation. Acts upstream of or within cytoskeleton organization. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in heart adult (RPKM 20.9), bladder adult (RPKM 15.7) and 20 other tissues See more
Orthologs
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Genomic context

See Map3k20 in Genome Data Viewer
Location:
2 C3; 2 43.11 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72115970..72272954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72285637..72442610)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 4 Neighboring gene STARR-seq mESC enhancer starr_04813 Neighboring gene predicted gene, 26408 Neighboring gene predicted gene, 52555 Neighboring gene STARR-positive B cell enhancer mm9_chr2:71987118-71987419 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71995766-71995967 Neighboring gene STARR-seq mESC enhancer starr_04815 Neighboring gene predicted gene, 52556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72234732-72234933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72235096-72235279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72237569-72237890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72239438-72239655 Neighboring gene STARR-seq mESC enhancer starr_04817 Neighboring gene STARR-positive B cell enhancer ABC_E9198 Neighboring gene predicted gene, 39847 Neighboring gene cell division cycle associated 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding PubMed 
enables ATP binding  
enables JUN kinase kinase kinase activity  
enables JUN kinase kinase kinase activity  
enables MAP kinase kinase kinase activity  
enables MAP kinase kinase kinase activity PubMed 
enables MAP kinase kinase kinase activity  
enables magnesium ion binding PubMed 
enables magnesium ion binding  
enables protein kinase activator activity  
enables protein kinase activator activity  
enables protein serine kinase activity  
enables protein serine/threonine kinase activity PubMed 
enables protein serine/threonine kinase activity  
enables ribosome binding  
enables ribosome binding  
enables small ribosomal subunit rRNA binding  
enables small ribosomal subunit rRNA binding  
enables stalled ribosome sensor activity  
Items 1 - 25 of 38
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling  
involved_in DNA damage checkpoint signaling  
acts_upstream_of GCN2-mediated signaling  
acts_upstream_of GCN2-mediated signaling  
involved_in JNK cascade PubMed 
involved_in JNK cascade  
involved_in MAPK cascade  
involved_in cellular response to UV-B  
involved_in cellular response to UV-B  
involved_in cellular response to gamma radiation  
involved_in cellular response to gamma radiation  
acts_upstream_of_or_within cytoskeleton organization PubMed 
involved_in embryonic digit morphogenesis PubMed 
involved_in embryonic digit morphogenesis  
involved_in intracellular signal transduction PubMed 
involved_in limb development PubMed 
involved_in limb development  
involved_in negative regulation of stress-activated protein kinase signaling cascade  
involved_in negative regulation of translation in response to endoplasmic reticulum stress  
involved_in p38MAPK cascade PubMed 
involved_in p38MAPK cascade  
involved_in p38MAPK cascade  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of mitotic DNA damage checkpoint  
involved_in positive regulation of mitotic DNA damage checkpoint  
acts_upstream_of positive regulation of programmed cell death  
acts_upstream_of positive regulation of programmed cell death  
involved_in protein autophosphorylation  
involved_in protein autophosphorylation  
involved_in protein phosphorylation PubMed 
involved_in protein phosphorylation  
acts_upstream_of_positive_effect pyroptotic inflammatory response  
acts_upstream_of_positive_effect pyroptotic inflammatory response  
involved_in signal transduction  
involved_in stress-activated MAPK cascade PubMed 
involved_in stress-activated MAPK cascade  
involved_in stress-activated protein kinase signaling cascade  
Items 1 - 25 of 38
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
is_active_in cytoplasm  
located_in cytosol  
located_in cytosol  
located_in nucleus PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 20
Names
MLK-like mitogen-activated protein triple kinase
MLK-related kinase
human cervical cancer suppressor gene 4 protein
leucine zipper- and sterile alpha motif kinase ZAK
leucine zipper- and sterile alpha motif-containing kinase
mitogen-activated protein kinase kinase kinase MLT
mixed lineage kinase-related kinase
sterile alpha motif and leucine zipper containing kinase AZK
NP_001158263.1
NP_075544.1
NP_835185.2
XP_006500060.1
XP_006500061.1
XP_030107797.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164791.2NP_001158263.1  mitogen-activated protein kinase kinase kinase 20 isoform 3

    See identical proteins and their annotated locations for NP_001158263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 3' exon but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL928699
    Consensus CDS
    CCDS50605.1
    UniProtKB/TrEMBL
    Q3TRG2
    Related
    ENSMUSP00000118983.2, ENSMUST00000135469.8
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. NM_023057.6NP_075544.1  mitogen-activated protein kinase kinase kinase 20 isoform 1

    See identical proteins and their annotated locations for NP_075544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL845274, AL928699
    Consensus CDS
    CCDS38143.1
    UniProtKB/Swiss-Prot
    Q3V1X8, Q8BR73, Q9ESL3, Q9ESL4
    Related
    ENSMUSP00000088334.6, ENSMUST00000090824.12
    Conserved Domains (2) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  3. NM_178084.5NP_835185.2  mitogen-activated protein kinase kinase kinase 20 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL928699
    UniProtKB/Swiss-Prot
    Q9ESL4
    Related
    ENSMUST00000150126.8
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    72115970..72272954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499997.4XP_006500060.1  mitogen-activated protein kinase kinase kinase 20 isoform X1

    See identical proteins and their annotated locations for XP_006500060.1

    UniProtKB/Swiss-Prot
    Q3V1X8, Q8BR73, Q9ESL3, Q9ESL4
    Conserved Domains (2) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. XM_030251937.2XP_030107797.1  mitogen-activated protein kinase kinase kinase 20 isoform X3

    UniProtKB/TrEMBL
    Q3TRG2
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  3. XM_006499998.4XP_006500061.1  mitogen-activated protein kinase kinase kinase 20 isoform X2

    Conserved Domains (2) summary
    cd09529
    Location:2292
    SAM_MLTK; SAM domain of MLTK subfamily
    PTZ00112
    Location:292411
    PTZ00112; origin recognition complex 1 protein; Provisional

RNA

  1. XR_004940679.1 RNA Sequence

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