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    terf2ip telomeric repeat binding factor 2, interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 407707, updated on 9-Dec-2024

    Summary

    Official Symbol
    terf2ipprovided by ZNC
    Official Full Name
    telomeric repeat binding factor 2, interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-131121-641
    See related
    Ensembl:ENSDARG00000103977 AllianceGenome:ZFIN:ZDB-GENE-131121-641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RAP1
    Summary
    Predicted to enable telomeric DNA binding activity. Predicted to be involved in positive regulation of canonical NF-kappaB signal transduction; regulation of nucleobase-containing compound metabolic process; and telomere maintenance. Predicted to act upstream of or within telomere maintenance. Predicted to be located in chromosome, telomeric region; cytoplasm; and nucleus. Predicted to be part of shelterin complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF2IP (TERF2 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See terf2ip in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (34598805..34614169, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (34623898..34639299, complement)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene glutamate metabotropic receptor 7 Neighboring gene uncharacterized LOC137488973 Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig-like domain 3 Neighboring gene si:ch1073-214b20.2 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC137488974

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables telomeric DNA binding  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA recombination at telomere  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in protection from non-homologous end joining at telomere  
    NOT involved_in protection from non-homologous end joining at telomere  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of double-strand break repair via homologous recombination  
    acts_upstream_of_or_within telomere maintenance  
    involved_in telomere maintenance via telomere lengthening  
    involved_in telomere maintenance via telomere lengthening  
    involved_in telomere maintenance via telomere lengthening  
    Component Evidence Code Pubs
    located_in chromosome  
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    located_in cytoplasm  
    located_in nucleus  
    located_in nucleus  
    part_of shelterin complex  

    General protein information

    Preferred Names
    telomeric repeat-binding factor 2-interacting protein 1
    Names
    RAP1 homolog
    TERF2-interacting telomeric protein 1
    TRF2-interacting telomeric protein 1
    repressor/activator protein 1 homolog
    zmp:0000000584

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001202416.1NP_001189345.1  telomeric repeat-binding factor 2-interacting protein 1

      See identical proteins and their annotated locations for NP_001189345.1

      Status: VALIDATED

      Source sequence(s)
      CABZ01048351, CU481774
      UniProtKB/Swiss-Prot
      Q5BKV6, Q6NYJ3
      UniProtKB/TrEMBL
      A0A0R4IRZ2, A0A8M1P1Q7
      Related
      ENSDARP00000131029.1, ENSDART00000158690.2
      Conserved Domains (3) summary
      cd11653
      Location:519613
      rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
      pfam08914
      Location:116177
      Myb_DNA-bind_2; Rap1 Myb domain
      pfam16589
      Location:1197
      BRCT_2; BRCT domain, a BRCA1 C-terminus domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      34598805..34614169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068216276.1XP_068072377.1  telomeric repeat-binding factor 2-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5BKV6, Q6NYJ3
      UniProtKB/TrEMBL
      A0A8M3B5S4
    2. XM_009296495.3XP_009294770.1  telomeric repeat-binding factor 2-interacting protein 1 isoform X2

      See identical proteins and their annotated locations for XP_009294770.1

      UniProtKB/Swiss-Prot
      Q5BKV6, Q6NYJ3
      UniProtKB/TrEMBL
      A0A0R4IRZ2, A0A8M1P1Q7
      Related
      ENSDARP00000139292.1, ENSDART00000171712.2
      Conserved Domains (3) summary
      cd11653
      Location:519613
      rap1_RCT; C-terminal domain of RAP1 recruits proteins to telomeres
      pfam08914
      Location:116177
      Myb_DNA-bind_2; Rap1 Myb domain
      pfam16589
      Location:1197
      BRCT_2; BRCT domain, a BRCA1 C-terminus domain
    3. XM_009296493.4XP_009294768.2  telomeric repeat-binding factor 2-interacting protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q5BKV6, Q6NYJ3
      UniProtKB/TrEMBL
      A0A8M3B5S4
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