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cpx-1 Putative complexin-1 [ Caenorhabditis elegans ]

Gene ID: 190666, updated on 9-Dec-2024

Summary

Official Symbol
cpx-1
Official Full Name
Putative complexin-1
Primary source
WormBase:WBGene00022271
Locus tag
CELE_Y73E7A.4
See related
AllianceGenome:WB:WBGene00022271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable SNARE binding activity. Predicted to be involved in modulation of chemical synaptic transmission; regulation of synaptic vesicle fusion to presynaptic active zone membrane; and synaptic vesicle exocytosis. Located in axon and synapse. Is expressed in nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1) and CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See cpx-1 in Genome Data Viewer
Location:
chromosome: I
Exon count:
2
Sequence:
Chromosome: I; NC_003279.8 (1594649..1596216, complement)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Tyrosine protein-kinase src-1 Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene Solute carrier family 35 member F1;Solute carrier family 35 member F2 Neighboring gene pseudo Neighboring gene Protein BFR2

Genomic regions, transcripts, and products

Genomic Sequence:
NC_003279.8

Bibliography

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables SNARE binding  
enables syntaxin binding  
Process Evidence Code Pubs
involved_in exocytosis  
involved_in modulation of chemical synaptic transmission  
involved_in neurotransmitter transport  
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane  
involved_in synaptic vesicle exocytosis  
Component Evidence Code Pubs
part_of SNARE complex  
located_in axon PubMed 
located_in cytoplasm  
located_in cytosol  
located_in synapse PubMed 
is_active_in terminal bouton  

General protein information

Preferred Names
Putative complexin-1
NP_490868.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    1594649..1596216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058467.5NP_490868.1  Putative complexin-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_490868.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9GUM7
    Conserved Domains (1) summary
    pfam05835
    Location:2127
    Synaphin; Synaphin protein
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