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Osm oncostatin M [ Mus musculus (house mouse) ]

Gene ID: 18413, updated on 9-Dec-2024

Summary

Official Symbol
Osmprovided by MGI
Official Full Name
oncostatin Mprovided by MGI
Primary source
MGI:MGI:104749
See related
Ensembl:ENSMUSG00000058755 AllianceGenome:MGI:104749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OncoM
Summary
Enables cytokine activity. Acts upstream of or within several processes, including negative regulation of meiotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; and tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in several structures, including aorta-gonad-mesonephros; future spinal cord; genitourinary system; submandibular gland; and trophectoderm. Orthologous to human OSM (oncostatin M). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in spleen adult (RPKM 1.9), thymus adult (RPKM 1.8) and 15 other tissues See more
Orthologs
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Genomic context

See Osm in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4186831..4191027)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4236785..4241026)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 10a Neighboring gene cytosolic arginine sensor for mTORC1 subunit 1 Neighboring gene predicted gene 11956 Neighboring gene STARR-seq mESC enhancer starr_28372 Neighboring gene STARR-seq mESC enhancer starr_28375 Neighboring gene leukemia inhibitory factor Neighboring gene predicted gene 11959

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables cytokine activity  
enables growth factor activity  
enables oncostatin-M receptor binding  
enables oncostatin-M receptor binding  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral response to pain PubMed 
involved_in immune response  
acts_upstream_of meiotic nuclear division PubMed 
acts_upstream_of_or_within negative regulation of hormone secretion  
acts_upstream_of_or_within negative regulation of meiotic nuclear division PubMed 
involved_in oncostatin-M-mediated signaling pathway  
involved_in oncostatin-M-mediated signaling pathway  
acts_upstream_of_or_within peripheral nervous system development PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade  
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of inflammatory response  
acts_upstream_of positive regulation of interleukin-17 production  
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of tyrosine phosphorylation of STAT protein  
acts_upstream_of_or_within response to heat PubMed 
acts_upstream_of_or_within tyrosine phosphorylation of STAT protein PubMed 
Component Evidence Code Pubs
located_in extracellular space  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013365.3NP_001013383.1  oncostatin-M precursor

    See identical proteins and their annotated locations for NP_001013383.1

    Status: VALIDATED

    Source sequence(s)
    AL807825
    Consensus CDS
    CCDS24382.1
    UniProtKB/Swiss-Prot
    P53347, Q3U1Y5, Q5SPX6
    Related
    ENSMUSP00000074708.3, ENSMUST00000075221.3
    Conserved Domains (2) summary
    pfam01291
    Location:43194
    LIF_OSM; LIF / OSM family
    pfam02956
    Location:191249
    TT_ORF1; TT viral orf 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4186831..4191027
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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