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    NRP2 neuropilin 2 [ Homo sapiens (human) ]

    Gene ID: 8828, updated on 10-Dec-2024

    Summary

    Official Symbol
    NRP2provided by HGNC
    Official Full Name
    neuropilin 2provided by HGNC
    Primary source
    HGNC:HGNC:8005
    See related
    Ensembl:ENSG00000118257 MIM:602070; AllianceGenome:HGNC:8005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NP2; NPN2; PRO2714; VEGF165R2
    Summary
    This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Jul 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Broad expression in placenta (RPKM 10.6), ovary (RPKM 9.8) and 20 other tissues See more
    Orthologs
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    Genomic context

    See NRP2 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (205682501..205798131)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (206164595..206280478)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (206547225..206662855)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907967 Neighboring gene par-3 family cell polarity regulator beta Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:205529451-205530018 Neighboring gene uncharacterized LOC124907968 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:205562341-205563540 Neighboring gene NANOG hESC enhancer GRCh37_chr2:205689833-205690426 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:205860967-205861560 Neighboring gene NANOG hESC enhancer GRCh37_chr2:205897477-205897980 Neighboring gene NANOG hESC enhancer GRCh37_chr2:206072806-206073307 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:206078371-206078958 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:206099834-206101033 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:206140682-206141288 Neighboring gene NANOG hESC enhancer GRCh37_chr2:206211338-206211871 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:206543139-206544338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:206549220-206549850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:206560188-206561022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:206572851-206573627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:206584967-206585532 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:206585533-206586096 Neighboring gene Sharpr-MPRA regulatory region 14521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:206611361-206611912 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:206612879-206613502 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:206613503-206614126 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:206614127-206614749 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:206617009-206618208 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:206646133-206646356 Neighboring gene NANOG hESC enhancer GRCh37_chr2:206661289-206661790 Neighboring gene uncharacterized LOC105373847 Neighboring gene NANOG hESC enhancer GRCh37_chr2:206700713-206701214 Neighboring gene uncharacterized LOC124907969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:206752118-206752618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:206752619-206753119 Neighboring gene RN7SK pseudogene 178

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of neuropilin 2 (NRP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of neuropilin 2 (NRP2) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC126574

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine binding PubMed 
    enables growth factor binding PubMed 
    enables heparin binding  
    enables identical protein binding PubMed 
    enables metal ion binding  
    enables protein binding PubMed 
    enables semaphorin receptor activity  
    enables semaphorin receptor activity PubMed 
    enables signaling receptor activity  
    enables vascular endothelial growth factor receptor activity PubMed 
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in angiogenesis PubMed 
    involved_in axon extension involved in axon guidance  
    involved_in axon guidance  
    involved_in axon guidance PubMed 
    involved_in branchiomotor neuron axon guidance  
    involved_in cell adhesion PubMed 
    involved_in cellular response to leukemia inhibitory factor  
    involved_in dorsal root ganglion morphogenesis  
    involved_in facial nerve structural organization  
    involved_in facioacoustic ganglion development  
    involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus  
    involved_in negative chemotaxis  
    involved_in nerve development  
    involved_in neural crest cell migration involved in autonomic nervous system development  
    involved_in outflow tract septum morphogenesis  
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of endothelial cell proliferation PubMed 
    involved_in regulation of postsynapse organization  
    involved_in semaphorin-plexin signaling pathway  
    involved_in sensory neuron axon guidance  
    involved_in sympathetic ganglion development  
    involved_in sympathetic neuron projection extension  
    involved_in sympathetic neuron projection guidance  
    involved_in trigeminal ganglion development  
    involved_in trigeminal nerve structural organization  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in ventral trunk neural crest cell migration  
    involved_in vestibulocochlear nerve structural organization  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    is_active_in axon  
    located_in extracellular region  
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    part_of semaphorin receptor complex PubMed 

    General protein information

    Preferred Names
    neuropilin-2
    Names
    neuropilin-2a(17)
    neuropilin-2a(22)
    neuropilin-2b(0)
    receptor for VEGF165 and semaphorins class3
    vascular endothelial cell growth factor 165 receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029567.2 RefSeqGene

      Range
      5002..120632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_003872.3NP_003863.2  neuropilin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_003863.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as NRP2a(17), lacks an alternate in-frame segment, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AC007362, AC007561, KF459587
      Consensus CDS
      CCDS46496.1
      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
      Related
      ENSP00000350432.5, ENST00000357785.10
      Conserved Domains (4) summary
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:845926
      DUF3481; C-terminal domain of neuropilin glycoprotein
    2. NM_018534.4NP_061004.3  neuropilin-2 isoform 4 precursor

      See identical proteins and their annotated locations for NP_061004.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as NRP2b(5), lacks the last two 3' exons and includes an alternate 3' exon, compared to variant 1. This results in a shorter isoform (4) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC007362, KF459587
      Consensus CDS
      CCDS2365.1
      UniProtKB/TrEMBL
      Q7Z3T9
      Related
      ENSP00000272849.3, ENST00000272849.7
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:822901
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    3. NM_201264.2NP_957716.1  neuropilin-2 isoform 6 precursor

      See identical proteins and their annotated locations for NP_957716.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as S9NRP2b, lacks several 3' exons and uses an alternate segment in the 3' coding region and 3' UTR, compared to variant 1. This results in a shorter, potentially soluble isoform (6) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC007362, KF459587
      Consensus CDS
      CCDS46499.1
      UniProtKB/TrEMBL
      A8K4G9
      Related
      ENSP00000387519.1, ENST00000417189.5
      Conserved Domains (3) summary
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    4. NM_201266.2NP_957718.1  neuropilin-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_957718.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as NRP2a(22), represents the longest transcript, and encodes the longest isoform (1).
      Source sequence(s)
      AC007362, AC007561, KF459587
      Consensus CDS
      CCDS2364.1
      UniProtKB/Swiss-Prot
      A0A024R3W6, A0A024R412, E9PF66, O14820, O14821, O60462, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
      UniProtKB/TrEMBL
      Q7Z3T9
      Related
      ENSP00000353582.3, ENST00000360409.7
      Conserved Domains (4) summary
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      pfam11980
      Location:850931
      DUF3481; C-terminal domain of neuropilin glycoprotein
    5. NM_201267.2NP_957719.1  neuropilin-2 isoform 5 precursor

      See identical proteins and their annotated locations for NP_957719.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as NRP2b(0), includes an alternate 3' sequence, compared to variant 1. This results in a shorter isoform (5) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC007362, KF459587
      Consensus CDS
      CCDS46498.1
      UniProtKB/TrEMBL
      X5D7M1
      Related
      ENSP00000349632.4, ENST00000357118.8
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:817896
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    6. NM_201279.2NP_958436.1  neuropilin-2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_958436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as NRP2a(0), lacks an in-frame segment and a following in-frame exon in the coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AC007362, AC007561, KF459587
      Consensus CDS
      CCDS46497.1
      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
      Related
      ENSP00000407626.2, ENST00000412873.2
      Conserved Domains (6) summary
      cd06263
      Location:646793
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      pfam11980
      Location:832906
      DUF3481; Domain of unknown function (DUF3481)
      smart00137
      Location:641794
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00231
      Location:277427
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00041
      Location:28141
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00057
      Location:280426
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      205682501..205798131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446170.1XP_047302126.1  neuropilin-2 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R3W6, A0A024R412, E9PF66, O14820, O14821, O60462, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
      UniProtKB/TrEMBL
      Q7Z3T9
    2. XM_047446172.1XP_047302128.1  neuropilin-2 isoform X2

      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
    3. XM_047446171.1XP_047302127.1  neuropilin-2 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R3W6, A0A024R412, E9PF66, O14820, O14821, O60462, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
      UniProtKB/TrEMBL
      Q7Z3T9
    4. XM_047446173.1XP_047302129.1  neuropilin-2 isoform X2

      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
    5. XM_017005188.3XP_016860677.1  neuropilin-2 isoform X5

      UniProtKB/TrEMBL
      X5D7M1
    6. XM_047446174.1XP_047302130.1  neuropilin-2 isoform X3

      UniProtKB/TrEMBL
      Q7Z3T9
    7. XM_047446175.1XP_047302131.1  neuropilin-2 isoform X4

      UniProtKB/TrEMBL
      X5D7M1
    8. XM_047446176.1XP_047302132.1  neuropilin-2 isoform X4

      UniProtKB/TrEMBL
      X5D7M1

    RNA

    1. XR_007083522.1 RNA Sequence

    2. XR_923057.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      206164595..206280478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344366.1XP_054200341.1  neuropilin-2 isoform X2

      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
    2. XM_054344363.1XP_054200338.1  neuropilin-2 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R3W6, A0A024R412, E9PF66, O14820, O14821, O60462, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
      UniProtKB/TrEMBL
      Q7Z3T9
    3. XM_054344367.1XP_054200342.1  neuropilin-2 isoform X3

      UniProtKB/TrEMBL
      Q7Z3T9
    4. XM_054344368.1XP_054200343.1  neuropilin-2 isoform X4

      UniProtKB/TrEMBL
      X5D7M1
    5. XM_054344364.1XP_054200339.1  neuropilin-2 isoform X1

      UniProtKB/Swiss-Prot
      A0A024R3W6, A0A024R412, E9PF66, O14820, O14821, O60462, Q53TQ4, Q53TS3, Q7LBX6, Q7LBX7, Q9H2D4, Q9H2D5, Q9H2E2, Q9H2E3, Q9H2E4, X5D2Q8
      UniProtKB/TrEMBL
      Q7Z3T9
    6. XM_054344365.1XP_054200340.1  neuropilin-2 isoform X2

      UniProtKB/TrEMBL
      B7ZL68, X5D7M1
    7. XM_054344369.1XP_054200344.1  neuropilin-2 isoform X4

      UniProtKB/TrEMBL
      X5D7M1
    8. XM_054344370.1XP_054200345.1  neuropilin-2 isoform X5

      UniProtKB/TrEMBL
      X5D7M1

    RNA

    1. XR_008486580.1 RNA Sequence

    2. XR_008486581.1 RNA Sequence

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