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Gramd1b GRAM domain containing 1B [ Rattus norvegicus (Norway rat) ]

Gene ID: 300644, updated on 9-Dec-2024

Summary

Symbol
Gramd1bprovided by RGD
Full Name
GRAM domain containing 1Bprovided by RGD
Primary source
RGD:1305443
See related
EnsemblRapid:ENSRNOG00000053577 AllianceGenome:RGD:1305443
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305443
Summary
Predicted to enable cholesterol binding activity; cholesterol transfer activity; and phospholipid binding activity. Predicted to be involved in cellular response to cholesterol; cholesterol homeostasis; and intracellular sterol transport. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Orthologous to human GRAMD1B (GRAM domain containing 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Adrenal (RPKM 464.1), Kidney (RPKM 85.4) and 4 other tissues See more
Orthologs
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Genomic context

See Gramd1b in Genome Data Viewer
Location:
8q22
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (49551642..49790965, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (40654492..40893869, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (44160634..44399110, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094120 Neighboring gene zinc finger protein 202 Neighboring gene sodium voltage-gated channel beta subunit 3 Neighboring gene uncharacterized LOC134480034 Neighboring gene uncharacterized LOC134480035 Neighboring gene uncharacterized LOC134480138

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cholesterol binding  
enables cholesterol binding  
enables cholesterol transfer activity  
enables cholesterol transfer activity  
enables phosphatidic acid binding  
enables phosphatidylserine binding  
Process Evidence Code Pubs
involved_in biological_process  
involved_in cellular response to cholesterol  
involved_in cholesterol homeostasis  
involved_in intracellular sterol transport  
Component Evidence Code Pubs
located_in endoplasmic reticulum  
is_active_in endoplasmic reticulum membrane  
located_in endoplasmic reticulum membrane  
is_active_in endoplasmic reticulum-plasma membrane contact site  
located_in endoplasmic reticulum-plasma membrane contact site  
located_in intracellular membrane-bounded organelle  
is_active_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
protein Aster-B
Names
GRAM domain-containing protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191616.1NP_001178545.1  protein Aster-B

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5ZLB1
    Related
    ENSRNOP00000110666.1, ENSRNOT00000172877.1
    Conserved Domains (2) summary
    cd13220
    Location:251344
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:519663
    DUF4782; Domain of unknown function (DUF4782)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    49551642..49790965 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265091.1XP_063121161.1  protein Aster-B isoform X9

    UniProtKB/TrEMBL
    A0A8I6A3S5, A0A8I6GLE8
    Related
    ENSRNOP00000086431.1, ENSRNOT00000098747.2
  2. XM_063265090.1XP_063121160.1  protein Aster-B isoform X8

    UniProtKB/TrEMBL
    A0A8I6GLE8
    Related
    ENSRNOP00000084513.2, ENSRNOT00000119190.2
  3. XM_063265084.1XP_063121154.1  protein Aster-B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZLB1
  4. XM_063265086.1XP_063121156.1  protein Aster-B isoform X4

    UniProtKB/TrEMBL
    D3ZYJ5
  5. XM_039081030.2XP_038936958.1  protein Aster-B isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZLB1, A0A8I6A887
    Related
    ENSRNOP00000088511.1, ENSRNOT00000099621.2
    Conserved Domains (2) summary
    cd13220
    Location:250343
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:518666
    DUF4782; Domain of unknown function (DUF4782)
  6. XM_063265085.1XP_063121155.1  protein Aster-B isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLB1
  7. XM_063265089.1XP_063121159.1  protein Aster-B isoform X7

    UniProtKB/TrEMBL
    A0A8I6GLE8
  8. XM_063265099.1XP_063121169.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  9. XM_063265088.1XP_063121158.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
    Related
    ENSRNOP00000094998.2, ENSRNOT00000097795.2
  10. XM_063265098.1XP_063121168.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  11. XM_063265092.1XP_063121162.1  protein Aster-B isoform X10

    UniProtKB/TrEMBL
    A0A8I6AAR1, A0A8I6GLE8
    Related
    ENSRNOP00000093680.2, ENSRNOT00000107338.2
  12. XM_063265093.1XP_063121163.1  protein Aster-B isoform X11

    UniProtKB/TrEMBL
    A0A8I6GLE8
  13. XM_063265094.1XP_063121164.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  14. XM_063265095.1XP_063121165.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  15. XM_063265097.1XP_063121167.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  16. XM_063265096.1XP_063121166.1  protein Aster-B isoform X6

    UniProtKB/TrEMBL
    A0A8I6GLE8
  17. XM_039081042.2XP_038936970.1  protein Aster-B isoform X12

    UniProtKB/TrEMBL
    A0A8I5ZZR8, A0A8I6GLE8
    Conserved Domains (2) summary
    cd13220
    Location:71164
    PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    pfam16016
    Location:339487
    DUF4782; Domain of unknown function (DUF4782)
  18. XM_063265087.1XP_063121157.1  protein Aster-B isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZLB1
  19. XM_063265100.1XP_063121170.1  protein Aster-B isoform X13

  20. XM_063265101.1XP_063121171.1  protein Aster-B isoform X14

RNA

  1. XR_010053942.1 RNA Sequence

  2. XR_010053943.1 RNA Sequence

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